Interferon and the epidermis: implications for cellular senescence.

Experimental Gerontology
M PeacockeB A Gilchrest

Abstract

Human keratinocytes are epithelial cells that cover the external surface of the body and function primarily to protect against physical, chemical and biological injury. Since 1975, serial cultivation of disaggregated human keratinocytes in vitro has been possible and these cultures have been utilized to assess in vitro physiological age. As has been demonstrated in human dermal fibroblasts harvested from donors of different ages, human epidermal keratinocytes from older donors manifest a decreased proliferative response to serum and to selected mitogens when compared to younger donors. Recent work suggests an increased sensitivity to negative growth modulators as well. The epidermis constantly renews itself. In normal skin, the majority of the cells in the germinative, basal cell layer are blocked in Go and do not cycle unless stimulated. Interferons (IFN) are a family of glycoproteins well known for their antiviral activity and their ability to inhibit growth and alter the behavior of various normal and transformed cell types, both in vitro and in vivo. As such, we examined intact skin for the presence of negative modulators of growth and demonstrated the presence, by immunofluorescence and Western blotting, of a protein of ap...Continue Reading

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Citations

May 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·H S BlackJ I Thornby
Sep 1, 1992·The British Journal of Dermatology·B A Gilchrest, M Yaar
Sep 1, 1994·Clinical and Experimental Dermatology·P C Van de KerkhofJ P Kuiper
Oct 1, 1990·The Journal of Dermatologic Surgery and Oncology·M Yaar, B A Gilchrest
Oct 24, 2003·American Journal of Clinical Dermatology·Gillian S Ashcroft, Jason J Ashworth
Mar 13, 2014·Reproductive Biology·Barbara Gawronska-KozakAnna Kur
Jan 13, 2012·Revista clínica española·F Jover-DíazC R Gallardo-Quesada

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