Interferon-based Adjuvant Chemoradiation for Resected Pancreatic Head Cancer: Long-term Follow-up of the Virginia Mason Protocol

Annals of Surgery
Flavio G RochaVincent J Picozzi

Abstract

To report the long-term impact of adjuvant interferon-based chemoradiation therapy (IFN-CRT) after pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma (PDAC). In 2003, we reported an actuarial 5-year overall survival (OS) of 55% (22 months median follow-up) using adjuvant IFN-CRT after PD. As the original cohort is now 10 years distant from PD, we sought to examine their actual survival, describe patterns of recurrence, and determine prognostic factors. From 1995 to 2002, 43 patients underwent PD for PDAC and received adjuvant IFN-CRT consisting of external-beam irradiation, continuous 5-fluorouracil infusion, weekly intravenous bolus cisplatin, and subcutaneous interferon-α. Survival was calculated by the method of Kaplan and Meier, and prognostic factors were compared using a log-rank test and a Cox proportional hazards model. With all patients at least 10 years from PD, the 5-year actual survival was 42% and 10-year actual survival was 28% with median OS of 42 months (95% confidence interval: 22-110 months). Nine patients survived beyond 10 years with 7 currently alive without evidence of disease. Initial recurrence included 4 local, 17 distant, and 4 combined sites at a median of 25 months. IFN-CRT was interrupted in...Continue Reading

References

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Citations

Feb 7, 2017·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kerri A OhmanWilliam G Hawkins
Jun 6, 2019·American Journal of Clinical Oncology·Aleksandr R BukatkoNosayaba Osazuwa-Peters
May 16, 2018·Cancer Biomarkers : Section a of Disease Markers·Zhuo LiuMan Xia
May 26, 2017·Biomedicines·Jing Li HuangMasato Yamamoto
Jan 3, 2021·Annals of Surgical Oncology·Flavio G Rocha
Jan 3, 2021·Critical Reviews in Oncology/hematology·Amber BlaauboerLeo J Hofland
Feb 7, 2021·Cellular and Molecular Gastroenterology and Hepatology·Emily P VonderhaarMichael B Dwinell
Dec 2, 2017·The Surgical Clinics of North America·Avram M CoopermanJustin G Steele

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Methods Mentioned

BETA
pancreatectomy
biopsy

Software Mentioned

MedCalc

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