PMID: 11921054Mar 29, 2002Paper

Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analyses

Annals of Neurology
R W BeckA W Sandrock

Abstract

The objective of this work was to assess the effect of interferon beta-1a (Avonex) on the rate of development of clinically definite multiple sclerosis and brain magnetic resonance imaging changes in subgroups based on type of presenting event, baseline brain magnetic resonance imaging parameters, and demographic factors in the Controlled High-Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS) trial. After the onset of a first demyelinating event, 383 patients with brain magnetic resonance imaging evidence of subclinical demyelination were treated with corticosteroids and randomly assigned to receive weekly intramuscular injections of 30 microg interferon beta-1a or placebo. The treatment effect within subgroups was assessed in proportional hazards models both for the development of clinically definite multiple sclerosis and for a combined outcome of development of clinically definite multiple sclerosis or >1 new or enlarging T2 lesions on brain magnetic resonance imaging. A beneficial effect of treatment was noted in all subgroups evaluated. Adjusted rate ratios for the development of clinically definite multiple sclerosis in the optic neuritis, brainstem-cerebellar, and spinal cord syndrome subgroups were 0.58 ...Continue Reading

References

Jun 1, 1988·Archives of Neurology·A Compston
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Apr 29, 1998·Brain : a Journal of Neurology·J I O'RiordanD H Miller
May 30, 2001·Lancet·G ComiUNKNOWN Early Treatment of Multiple Sclerosis Study Group

❮ Previous
Next ❯

Citations

Sep 20, 2005·Journal of Neurology·Ludwig KapposRaija L P Lindberg
Nov 16, 2007·Journal of Neurology·Chris PolmanUNKNOWN BENEFIT investigators
Mar 28, 2009·Journal of Neurology·Bernd C KieseierOlaf Stüve
Feb 5, 2013·Journal of Neurology·Roberto D'AlessandroMaurizio Leone
Oct 7, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yan-Ming ChenJieh-Ren Jou
Oct 4, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco Rovaris
May 23, 2003·Current Neurology and Neuroscience Reports·I A Scarisbrick, M Rodriguez
Dec 25, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Corey A McGraw, Fred D Lublin
Aug 26, 2006·Nature Clinical Practice. Neurology·Ruth Ann Marrie, Richard A Rudick
Mar 3, 2006·The New England Journal of Medicine·Richard A RudickUNKNOWN SENTINEL Investigators
Mar 3, 2006·The New England Journal of Medicine·Chris H PolmanUNKNOWN AFFIRM Investigators
Jul 12, 2008·The Neurologist·Catherine A Kernich
Jan 6, 2012·The Neurologist·Jane W Chan
Jan 2, 2013·Therapeutic Advances in Neurological Disorders·Paul I Creeke, Rachel A Farrell
Nov 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Inês Brás MarquesLívia Sousa
Jun 26, 2008·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Edward J AtkinsValérie Biousse
Sep 23, 2008·Der Nervenarzt·R A Linker, B C Kieseier
Apr 1, 2003·Expert Opinion on Investigational Drugs·Heinz Wiendl, Bernd C Kieseier
Jun 18, 2011·Clinical Neurology and Neurosurgery·Yaou LiuKuncheng Li
Dec 19, 2014·Rinshō shinkeigaku = Clinical neurology·Yuji Nakatsuji
Oct 16, 2004·Journal of Evaluation in Clinical Practice·Pierluigi RussoPlacido Bramanti
Apr 22, 2015·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Anthony TraboulseeDavid K B Li
Sep 8, 2004·Ophthalmology·Nathalie J Collignon-RobeJoseph F Rizzo
Sep 22, 2006·Lancet Neurology·Elliot FrohmanLaura Balcer
Jun 1, 2009·Acta Neuropsychiatrica·Sven G MeuthHeinz Wiendl
Nov 26, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Tim SpelmanUNKNOWN MSBasis (an MSBase Substudy) Investigators
Jun 1, 2017·The New England Journal of Medicine·Luanne M MetzUNKNOWN Minocycline in MS Study Team
Jun 5, 2004·Clinical Neurology and Neurosurgery·A D Sadovnick
Nov 13, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Aurélie RuetBruno Brochet
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·J K SwantonD H Miller
Jan 1, 2012·Journal of Central Nervous System Disease·Alexis Clapin
Apr 26, 2017·The Cochrane Database of Systematic Reviews·Graziella FilippiniGeorgia Salanti
Jan 9, 2010·Multiple Sclerosis : Clinical and Laboratory Research·O GarceaM Rivera Kindel
Jun 5, 2003·Annals of Neurology·Frederik BarkhofUNKNOWN Early Treatment of Multiple Sclerosis Study Group
Jul 9, 2008·Current Opinion in Neurology·Carolina CiumasPhilippe Ryvlin
Mar 9, 2019·Neurochemical Research·Ahdeah Pajoohesh-Ganji, Robert H Miller
Jun 5, 2019·Continuum : Lifelong Learning in Neurology·Luanne M Metz
Jun 15, 2012·Journal of Magnetic Resonance Imaging : JMRI·René M VigevenoFrederik Barkhof

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.