Interferon-beta fails to protect in a model of transient focal stroke

Stroke; a Journal of Cerebral Circulation
Carolina M MaierPak H Chan

Abstract

Compelling evidence supporting the role of inflammation in the development of cerebral infarction has focused attention on the potential of antiinflammatory treatment strategies for stroke. Interferon (IFN)-beta, an immunomodulatory agent approved for treatment of multiple sclerosis, is being evaluated in a phase I clinical trial in acute ischemic stroke. In the present study, we evaluated the effects of wild-type rat IFN-beta and its pegylated counterpart (PEG-IFN-beta) in a model of focal ischemia and reperfusion. After 60 minutes of middle cerebral artery occlusion, rats (n=12/group) were treated with IV tail injections of 8 or 16 mug of IFN-beta in 300 muL of PBS once daily for 3 or 7 days or with IV or SC injections of PEG-IFN-beta for 1 day. The animals were assessed daily for weight and for neurological findings. Additional animals underwent complete hematology and chemistry profiles, as well as complete multiorgan necropsy studies. All of the brain tissue was evaluated for assessment of infarct areas, neutrophil infiltration, and presence of hemorrhagic transformations. IFN-beta and PEG-IFN-beta failed to protect against experimental ischemic brain injury as assessed by histopathology and neurological outcome. Furthermo...Continue Reading

References

Nov 11, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M FujimuraP H Chan
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wouter B VeldhuisPeter R Bär
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wouter B VeldhuisKlaas Nicolay
Dec 14, 2004·Journal of Neurology·Helen Tremlett, Joel Oger
May 11, 2005·Expert Opinion on Investigational Drugs·Xinkang Wang

❮ Previous
Next ❯

Citations

Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brenda MarshMary P Stenzel-Poore
Sep 22, 2015·International Journal of Molecular Sciences·Brandon J DixonJohn H Zhang
Jan 10, 2016·Journal of the American Heart Association·Ping-Chang KuoJui-Hung Yen
Dec 17, 2008·Stroke; a Journal of Cerebral Circulation·Maria PhilipSean I Savitz
Oct 16, 2018·Journal of Neuroscience Research·Madhuri WanvePallab Bhattacharya
Feb 20, 2019·Journal of Neuroinflammation·Giuseppa MudòLuigi M Grimaldi
Aug 5, 2017·Frontiers in Cellular Neuroscience·Shelly A CruzHsiao-Huei Chen
May 19, 2018·Therapeutic Advances in Neurological Disorders·Mirjam DreikornPeter Kraft
Aug 7, 2019·Glia·Ashley McDonough, Jonathan R Weinstein
Mar 4, 2017·Molecular Genetics and Genomics : MGG·Ekaterina V MedvedevaLyudmila V Dergunova
Feb 11, 2021·Journal of Clinical Medicine·Athina-Maria AloizouEfthimios Dardiotis
May 11, 2021·Journal of Molecular Neuroscience : MN·Yi-Sha GuoXia Bi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.