PMID: 9663561Jul 15, 1998Paper

Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro

Journal of Neuroimmunology
O MalikN J Scolding

Abstract

The central nervous system response to injury and inflammation commonly includes astrocytosis. This process, which is manifest by astrocyte hypertrophy and proliferation, is particularly prominent in multiple sclerosis (MS), where in chronic lesions it may contribute to the lack of repair by restricting the migration of remyelinating cells. Interferon-beta (IFN-beta) modestly reduces the frequency of relapses in MS and may have a small effect on the accumulation of permanent disability. Here, we show that IFN-beta inhibits the in vitro proliferative response of rodent astrocytes to a wide variety of growth factors and cytokines. Although important species differences exist in these glial responses this previously unrecognised property of IFN-beta may have implications for reducing astrocytosis and thereby promoting endogenous repair.

References

Feb 1, 1990·Trends in Neurosciences·G P WilkinA J Cholewinski
Jan 1, 1991·Glia·M E HattenC A Mason
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V W YongJ P Antel
Dec 1, 1990·Journal of Neuroimmunology·B P BarnaR M Ransohoff
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jun 1, 1994·Glia·Y Shao, K D McCarthy
Jun 1, 1994·Progress in Neurobiology·N J ScoldingD A Compston
Jan 1, 1994·Annals of Neurology·W BrückH Lassmann
Feb 1, 1993·Annals of Neurology·J W PrineasE S Cho
Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen
Oct 1, 1996·Clinical Immunology and Immunopathology·B G Arnason
Jan 1, 1997·Journal of Neuroimmunology·G L HallN J Scolding
Dec 1, 1996·Annals of Neurology·H P Hartung, B C Kieseier
Mar 1, 1996·Trends in Neurosciences·R H Miller
Jun 1, 1997·Trends in Genetics : TIG·S SawcerA Compston

❮ Previous
Next ❯

Citations

Jun 3, 2008·Cellular and Molecular Life Sciences : CMLS·A NairS D Miller
Sep 30, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jian Hong, George J Hutton
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Hohlfeld
May 31, 2011·Best Practice & Research. Clinical Anaesthesiology·Eva Zindler, Frauke Zipp
Feb 2, 2010·Journal of Neuroimmunology·Daniele VergaraMichele Maffia
Aug 5, 2004·Annals of Neurology·Jörg KrausBritta Engelhardt
Sep 8, 2010·Expert Review of Neurotherapeutics·Rina Aharoni
May 13, 2008·Journal of Neuroimmunology·Tapas K MakarSuhayl Dhib-Jalbut
Jan 18, 2006·Clinical Neurology and Neurosurgery·Dimitrios KarussisOded Abramsky
Oct 17, 2009·Nanotechnology·Daniele VergaraRoss Rinaldi
Aug 19, 2007·Neuroimmunomodulation·Olga BarcaVíctor M Arce
Oct 9, 2012·Expert Review of Neurotherapeutics·Felix LuessiFrauke Zipp
Oct 22, 2014·Expert Review of Neurotherapeutics·Felix LuessiFrauke Zipp
Jun 18, 2020·International Journal of Molecular Sciences·Kim M A De Kleijn, Gerard J M Martens
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabrizio G MastronardiMario A Moscarello

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.