PMID: 9660244Jul 11, 1998Paper

Interferon-containing controlled-release polymers for localized cerebral immunotherapy

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
M WiranowskaH Brem

Abstract

Controlled-release ethylene-vinyl acetate copolymers (EVAc), which were used previously for the in vivo intracerebral delivery of chemotherapeutics, were evaluated as a possible route of localized intracerebral delivery of interferon (IFN). Natural mouse IFN-alpha/beta (Mu-IFN-alpha/beta) was incorporated into polymers at 5% or 10% by weight with 2 x 10(4) U or 4 x 10(4) U, respectively. In vitro and in vivo studies of the release of Mu-IFN-alpha/beta from EVAc polymers showed the released IFN to be biologically active, as determined by the inhibition assay of viral cytopathic effect (CPE). Evaluation of the in vitro kinetics of release showed that most of the IFN activity was released in the first 4 days, with the rest being released thereafter. The in vivo kinetic release of Mu-IFN-alpha/beta from intracerebrally implanted polymers showed that most of the IFN activity was released within 24 h after polymer implantation in the hemisphere ipsilateral to the polymer. This IFN activity gradually decreased over the next 72 h, with a significant linear trend (p < 0.0001). The hemisphere contralateral to the implanted polymer showed no significant levels of IFN activity throughout the 4 days of evaluation. By contrast, blood levels ...Continue Reading

References

Jan 1, 1979·International Journal of Immunopharmacology·D F HanleyW E Stewart
Jul 1, 1990·Clinical and Experimental Immunology·M C KuppnerN de Tribolet
Sep 28, 1990·Science·R Langer
Jun 1, 1989·Journal of Interferon Research·M WiranowskaL D Prockop
May 1, 1989·Journal of Neuro-oncology·P Elworthy, E Hitchcock
Jun 1, 1988·Journal of Neurosurgery·R BashirK Hottleman
Jun 1, 1987·Journal of Interferon Research·M KurokiS Kobayashi
May 1, 1980·Molecular Immunology·M Wiranowska-StewartW E Stewart
Jun 15, 1981·International Journal of Cancer. Journal International Du Cancer·D Lundblad, E Lundgren
Mar 1, 1981·Journal of Biomedical Materials Research·R LangerD Tapper
Mar 1, 1995·Annals of Biomedical Engineering·R Langer
Sep 4, 1995·International Journal of Cancer. Journal International Du Cancer·J D WeingartH Brem
Jan 1, 1993·Journal of Neuro-oncology·M Wiranowska, A K Naidu
Jan 15, 1993·Cancer·C J KimT Tomoyoshi
Aug 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R MenziesN Hall

❮ Previous
Next ❯

Citations

Oct 30, 2007·Neurologic Clinics·Ashok R AsthagiriMark E Shaffrey
Jun 12, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Susanne BeyerMatthias G Wacker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.