PMID: 6159548Nov 6, 1980Paper

Interferon-dependent induction of mRNA activity for (2'-5')oligo-isoadenylate synthetase

Nature
L Shulman, M Revel

Abstract

At least three different enzymes involved in the regulation of protein synthesis are induced in a variety of cells by interferon (IFN). Sensitive assays for these enzymes have been developed and used to establish the specificity, dose dependence and time course of their induction by IFN. One of these enzymes, the oligo-isoadenylate synthetase E, whose product (2'-5')pppApApA activates the latent ribonuclease F, is increased over 50-fold after IFN treatment. We describe here the assay for an mRNA from IFN-treated mouse L cells, that produces oligo-isoadenylate synthetase activity when injected into Xenopus oocytes. This mRNA is found in the cells only after exposure to IFN. The mRNA increases in mouse L cells with the same time course as the enzyme activity itself. In particular, there is a 3-h lag period between IFN addition and the onset of enzyme and mRNA accumulation. Using anti-IFN antibodies, we show that during this lag period the continued interaction of IFN with the cells is necessary for the full induction of the oligo-isoadenylate synthetase.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A KimchiM Revel
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P J FarrellP Lengyel
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A ZilbersteinM Revel
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E SlatteryP Lengyel
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Feb 1, 1974·Virology·B Berman, J Vilcek

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Citations

May 1, 1984·Somatic Cell and Molecular Genetics·L M ShulmanF H Ruddle
Jan 14, 1983·Biochemical and Biophysical Research Communications·G HuezB Lebleu
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M FellousM Revel
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H SoreqI Silman
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G MerlinM Revel
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Y OzakiD S Duch
Feb 11, 1985·Nucleic Acids Research·E C ZwarthoffJ Trapman
Jul 24, 1981·Nucleic Acids Research·R Miskin, H Soreq
Sep 1, 1982·European Journal of Biochemistry·M Verhaegen-Lewalle, J Content
Jan 1, 1985·CRC Critical Reviews in Biochemistry·H Soreq
Jun 1, 1986·Journal of Cellular Physiology·M MorangeP Lebon
Feb 14, 1985·Nature·M Clemens
Aug 7, 2021·The Journal of Biological Chemistry·Lilian Cristina RussoNicolas Carlos Hoch

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