Interferon enhances the amount of membrane-bound beta2-microglobulin and its release from human Burkitt cells

European Journal of Immunology
M FellousI Gresser

Abstract

Human leukocytes interferon (HuIFN-A) increased the amount of beta2-microglobulin on the surface of human Burkitt lymphoma cells (Ramos) and also increased the amount released into the culture medium. The effect was observed 1 h after addition of IFN. These results suggest that the increase in beta2-microglobulin on the cell surface of IFN-treated cells is not due to a decreased shedding of antigen from the cell surface, nor an "unmasking" of surface antigen, but rather to an increased synthesis of antigen.

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May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Y BashamT C Merigan
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Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·K E MogensenP Eid

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