Interferon-free regimens for the treatment of hepatitis C virus in liver transplant candidates or recipients

World Journal of Gastroenterology : WJG
Evangelos CholongitasGeorge Papatheodoridis

Abstract

The goal of therapy in chronic hepatitis C virus (HCV) infection is sustained virological response (SVR) which reflects HCV eradication. Treatment against HCV has dramatically improved with the recent availability of direct-acting antivirals (DAAs) including sofosbuvir, simeprevir, daclatasvir, ledipasvir/sofosbuvir, paritaprevir/ombitasvir and dasabuvir. Carefully selected combinations of these DAAs offer the potential for highly effective all-oral safe regimens even for patients with decompensated cirrhosis or liver transplant (LT) recipients. Like all current protease inhibitors, simeprevir and paritaprevir should not be used in patients with Child C cirrhosis, while sofosbuvir and ledipasvir/sofosbuvir should not be given in patients with severe renal impairment and glomerular filtration rate less than 30 mL/min. Drug-drug interactions may still occur with the current DAAs particularly in post-LT patients, in whom simeprevir should not be co-administered with cyclosporine and dose adjustments of calcineurin inhibitors are required in case of regimens including the ritonavir boosted paritaprevir. Phase II clinical trials and real life cohort studies have shown that sofosbuvir based combinations are safe and can achieve impro...Continue Reading

References

Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Russell H WiesnerUNKNOWN International Liver Transplantation Society Expert Panel
Mar 16, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jul 3, 2004·Journal of Viral Hepatitis·G V Papatheodoridis, E Cholongitas
Jun 7, 2007·World Journal of Gastroenterology : WJG·Miriam J Alter
Feb 21, 2008·Alimentary Pharmacology & Therapeutics·E Cholongitas, G V Papatheodoridis
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Daniel Lavanchy
Jan 11, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Bruno Roche, Didier Samuel
Nov 17, 2012·World Journal of Gastroenterology : WJG·Alexandra Alexopoulou, George V Papatheodoridis
Dec 4, 2012·Best Practice & Research. Clinical Gastroenterology·Benjamin Maasoumy, Heiner Wedemeyer
Dec 4, 2012·Best Practice & Research. Clinical Gastroenterology·Norah Terrault
Mar 2, 2013·Expert Opinion on Investigational Drugs·David Alan Herbst, K Rajender Reddy
Jan 1, 2014·Current Medicinal Chemistry·I GentileG Borgia
Mar 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hiromitsu KumadaEric Hughes
May 2, 2014·Seminars in Liver Disease·Sabela LensXavier Forns
Jan 6, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsFrançois Habersetzer
Feb 15, 2015·The Annals of Pharmacotherapy·Olga M KlibanovBarbara Santevecchi
Feb 28, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Surakit PungpapongAndrew P Keaveny
Apr 1, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Julio A GutierrezAdam Peyton

❮ Previous
Next ❯

Citations

Apr 2, 2016·Zeitschrift für Rheumatologie·N Blank, H-M Lorenz
Oct 29, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tomohiro TanakaNorihiro Kokudo
Nov 23, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kiyohiko OmichiNorihiro Kokudo
Jun 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewelina KrolBoguslaw Szewczyk
Jul 20, 2016·World Journal of Hepatology·Aldo Bonaventura, Fabrizio Montecucco
Jun 21, 2020·Gastroenterología y hepatología·José CastelloteMaría Buti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.