Interferon-Free Therapy for Hepatitis C in Liver Transplant Recipients

Transplantation
Yoshihide Ueda, Shinji Uemoto

Abstract

Recurrence of hepatitis C after liver transplantation is a major problem; it is characterized by high hepatitis C virus (HCV)-RNA, rapid progression, and cholestatic hepatitis. Treatment for HCV infection with peginterferon and ribavirin has been administered to prevent progression of hepatitis C after liver transplantation. However, it has low efficacy and causes many adverse events, including immune-mediated graft dysfunction. Interferon-containing regimens with direct-acting antivirals (DAAs) improve treatment efficacy but DAAs cause serious adverse events and drug-drug interactions. Recent studies have demonstrated the efficacy and safety of interferon-free therapy with DAAs before and after liver transplantation, which has ushered in a new era in the strategy for treating HCV in transplant recipients. Interferon-free therapies are safe and effective in patients before and after liver transplantation as well as in those with severe cholestatic hepatitis C. Several obstacles must be overcome before the widespread adoption of interferon-free therapy, including drug-drug interactions, DAA-resistant HCV, treatment for decompensated cirrhosis, and treatment for renal failure. These problems are expected to be solved in the near ...Continue Reading

References

Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R SreekumarM R Charlton
Jun 8, 2001·Transplantation·J P OngB Yen-Lieberman
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Koichi WatashiKunitada Shimotohno
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marcelo KugelmasGregory T Everson
Nov 3, 2004·Journal of Hepatology·Ulf P NeumannPeter Neuhaus
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas D SchianoAndrea D Branch
Apr 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina BerenguerJoaquín Berenguer
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C S WangK Richardson
Jan 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas WalterOlivier Boillot
Mar 21, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luca S BelliGiovambattista Pinzello
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nevin YilmazRobert A Fisher
Jul 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Inmaculada FernándezEnrique Moreno
Dec 17, 2009·Gastroenterology·Christoph Sarrazin, Stefan Zeuzem
Oct 30, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Tarun K NarangMark W Russo
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Varun GargXia Luo
Aug 1, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marc L WeberJohn R Lake
Dec 4, 2012·Best Practice & Research. Clinical Gastroenterology·Johannes Vermehren, Christoph Sarrazin
Dec 4, 2012·Best Practice & Research. Clinical Gastroenterology·Norah Terrault
Apr 19, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J FontanaW T Symonds
May 23, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Surakit PungpapongAndrew P Keaveny
Oct 12, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michel BléMarina Berenguer
Mar 19, 2014·Gastroenterology·Jean-Michel Pawlotsky
Apr 22, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George M Abraham, Linda M Spooner
May 2, 2014·Seminars in Liver Disease·Sabela LensXavier Forns
Sep 2, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Yoshihide UedaShinji Uemoto
Nov 12, 2014·The New England Journal of Medicine·Paul Y KwoXavier Forns
Jan 6, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier FornsFrançois Habersetzer

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Citations

Jan 20, 2016·Expert Review of Gastroenterology & Hepatology·Ching-Sheng Hsu, Jia-Horng Kao
Dec 22, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masaki HondaYukihiro Inomata
Dec 26, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Melissa LaubJennifer Byrns

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