Interferon gamma-1b for the treatment of fibrosis in chronic hepatitis C infection

Journal of Viral Hepatitis
A J MuirDon C Rockey

Abstract

Given that the complications of hepatitis C are due to fibrosis, we hypothesized that the antifibrotic effects of interferon gamma on stellate cells would lead to beneficial effects in patients with hepatitis C. Thus, we evaluated the safety and efficacy of interferon gamma-1b in patients with hepatitis C. A cohort of 20 patients with chronic hepatitis C who failed or were intolerant to previous interferon-alpha-based regimens received 200 mug of interferon gamma-1b subcutaneously three times weekly for 24 weeks. Liver biopsy was performed prior to and at the end of treatment. Biopsies were evaluated by a single blinded pathologist using the Knodell system modified by Ishak, and fibrosis was also quantitated by morphometric analysis. The study population was 75% male and 70% Caucasian. Mean age was 47.9 +/- 7.5 years. Eighteen of 20 patients completed therapy. One patient discontinued therapy because of constitutional symptoms. One patient discontinued therapy because of elevated aminotransferases greater than twice baseline. No serious adverse events occurred. Morphometric analysis revealed that six patients (30%) had >1% absolute reduction in fibrosis score. Four of 20 (20%) patients had improvement in Ishak fibrosis scores a...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C RockeyS L Friedman
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J CzajaM A Zern
Nov 30, 1989·The New England Journal of Medicine·A M Di BisceglieJ H Hoofnagle
Dec 1, 1971·The American Journal of Digestive Diseases·R D SolowayW H Summerskill
Jan 1, 1981·Cancer·A B MillerA Winkler
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z ShiD C Rockey
Dec 31, 1997·Annals of Internal Medicine·J F DufourM M Kaplan
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
Feb 19, 2002·Annals of Internal Medicine·Yngve Falck-YtterArthur J McCullough
Mar 2, 2002·Journal of Clinical Gastroenterology·Andrew J Muir, Dawn Provenzale
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jorge Rakela, Hugo E Vargas
Oct 19, 2002·The American Journal of Gastroenterology·Arie RegevEugene R Schiff
Jan 4, 2003·Gastroenterology·Jules L DienstagEugene R Schiff
Jul 23, 2003·Digestive Diseases and Sciences·Asma ArifDaniel H Gregory
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David R NelsonGary L Davis
Oct 10, 2003·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Z KahveciI Cavusoglu
Nov 25, 2003·Alcoholism, Clinical and Experimental Research·Charles S LieberUNKNOWN Veterans Affairs Cooperative Study 391 Group
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre BedossaValerie Paradis
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorPatrick Colin
Nov 30, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Alex Yui HuiJoseph Jao-Yiu Sung
Feb 11, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey

❮ Previous
Next ❯

Citations

Apr 29, 2010·Current Gastroenterology Reports·Alexander James Thompson, Keyur Patel
Aug 6, 2010·The Journal of Biological Chemistry·Zengdun Shi, Don C Rockey
Dec 5, 2006·Current Opinion in Rheumatology·Frances A Y Borg, David A Isenberg
Apr 11, 2008·Journal of Gastroenterology and Hepatology·Won-Il Jeong, Bin Gao
Aug 30, 2007·Critical Reviews in Therapeutic Drug Carrier Systems·Kun Cheng, Ram I Mahato
Jul 24, 2013·Journal of Biotechnology·Bevan Kai-Sheng ChungDong-Yup Lee
Oct 1, 2007·Expert Review of Gastroenterology & Hepatology·Bin GaoWon-Il Jeong
Jan 12, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Don C Rockey
Apr 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yi-Jun WuHong-Lei Weng
Feb 22, 2011·Cytokine & Growth Factor Reviews·Christopher J HorrasKristen A Mitchell
Nov 6, 2008·Clinics in Liver Disease·Roben G GielingDerek A Mann
Nov 6, 2008·Clinics in Liver Disease·Don C Rockey
Dec 13, 2006·Clinics in Liver Disease·Don C Rockey
Dec 14, 2006·Clinics in Liver Disease·Don C Rockey
Oct 30, 2007·Journal of Applied Toxicology : JAT·Pablo Muriel, Yadira Rivera-Espinoza
Jul 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong-Lei WengSteven Dooley
Nov 30, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Won-Il JeongBin Gao
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Won-Il JeongBin Gao
Jul 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ekihiro Seki, Robert F Schwabe
Mar 19, 2015·The New England Journal of Medicine·Don C RockeyJoseph A Hill
Nov 2, 2011·Therapeutic Advances in Gastroenterology·Michal Cohen-Naftaly, Scott L Friedman
Feb 2, 2018·Journal of Digestive Diseases·Rilu FengHong-Lei Weng
Dec 9, 2017·Frontiers in Pharmacology·Xiaoyi LiRuixin Zhu
May 27, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracy A DelaneyAnthony J Coyle
Aug 28, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Reham M DawoodMostafa K El Awady
Jul 17, 2018·Frontiers in Immunology·Mengjia TangXijie Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Don C RockeyScott L Friedman
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Don C Rockey
The Journal of Pharmacology and Experimental Therapeutics
W I HagensK Poelstra
American Journal of Physiology. Gastrointestinal and Liver Physiology
Liu YangDon C Rockey
© 2022 Meta ULC. All rights reserved