PMID: 2121524Sep 17, 1990Paper

Interferon-gamma activates the cleavage of double-stranded RNA by bovine seminal ribonuclease

FEBS Letters
C H ScheinS A Benner

Abstract

Bovine seminal ribonuclease (BS-RNase), a dimeric homologue of RNase A, cleaves both single- and double-stranded RNA and inhibits the growth of tumor cells. Its catalytic activity against double-stranded RNA, either homopolymeric ([3H]polyA/polyU) or mixed sequence, is enhanced by bovine or human recombinant interferon-gamma (IFN-gamma). Activation is seen with as little as 4-10 interferon units per assay. Enhancing the degradation of double-stranded RNA, an intermediate in the growth cycle of many viruses, could contribute to IFN-gamma's ability to control cell growth and induce an antiviral state.

References

Oct 1, 1988·Journal of Cellular Physiology·M F DuboisO Bensaude
Jan 1, 1988·Progress in Nucleic Acid Research and Molecular Biology·C E Samuel
Jun 2, 1989·Science·J M Meegan, P I Marcus
Aug 30, 1988·Biochemical and Biophysical Research Communications·N TsuruokaN Sato
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D Picard, W Schaffner

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Citations

Apr 7, 2015·Molekuliarnaia biologiia·O N Il'inskaia, R Shakh Makhmud
Jan 1, 2014·Molecular Biology·O N Ilinskaya, R Shah Mahmud
Jun 6, 2018·Frontiers in Immunology·Lu LuEster Boix
Sep 6, 2018·Molecular Neurobiology·Catherine H Schein
Feb 13, 2001·Cytokine·C MurphyM Giese

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