PMID: 8953408Nov 1, 1996Paper

Interferon-gamma as a regulator of squamous differentiation

Journal of Dermatological Science
N SaundersA Jetten

Abstract

Interferon-gamma (IFN-gamma) is a potent immunomodulatory molecule. Recent studies demonstrate that IFN-gamma can induce growth arrest and differentiation in epithelial cells. The signalling pathways controlling growth and differentiation in epithelial cells appears to be different to those regulating immune functions in non-epithelial cells and appear to impact on key cell cycle regulatory genes such as cdk1 and E2F1. In addition, studies with IFN-gamma have highlighted the complexity of the signalling pathways regulating the expression of differentiation markers in squamous differentiating epithelia. Given the actions of IFN-gamma upon epithelial cell growth and differentiation it should be considered a potential regulator of both immune and epithelial cell targets in various inflammatory pathologies such as psoriasis.

References

Mar 1, 1992·The Journal of Investigative Dermatology·S MichelU Reichert
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K W MarvinA M Jetten
Feb 1, 1992·The Journal of Investigative Dermatology·A ScheyniusH Valdimarsson
Dec 1, 1990·The Journal of Cell Biology·E Fuchs
Jan 1, 1986·Ultrastructural Pathology·B J NickoloffV Morhenn
Feb 1, 1995·Molecular and Cellular Biology·V BrikenP Staeheli
Aug 1, 1994·American Journal of Respiratory Cell and Molecular Biology·N A SaundersA M Jetten
May 1, 1993·American Journal of Respiratory Cell and Molecular Biology·C V Harding

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Citations

Aug 25, 2011·Archives of Dermatological Research·Cheryl M SweeneyBrian Kirby
Jan 23, 1998·Free Radical Biology & Medicine·C P TurnerO T Jones
Dec 21, 2002·International Journal of Dermatology·Isabelle TenaudBrigitte Dreno
Jun 26, 2003·Experimental Dermatology·Vijaya ChaturvediBrian J Nickoloff
Nov 26, 2002·The Journal of Investigative Dermatology·Karla CauzaDagmar Foedinger
Jan 19, 2006·The Journal of Investigative Dermatology·Gen NakanishiAnton M Jetten
May 31, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yuan LiuXinwen Wang
Aug 7, 1999·The Journal of Biological Chemistry·V ChaturvediB J Nickoloff
Jul 12, 2019·Journal of Virology·Gaurav RaikhyJason M Bodily
Mar 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M JacksonR C McKenzie
Mar 20, 1999·Biochemical and Biophysical Research Communications·S JanssensJ Geysen
Aug 1, 1997·The Journal of Investigative Dermatology·S J JonesN A Saunders
Aug 11, 2021·Lipids in Health and Disease·Bai RuiyangFu Siqi

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