PMID: 2117474Jul 1, 1990Paper

Interferon gamma encapsulated into liposomes enhances the activity of monocytes and natural killer cells and has antiproliferative effects on tumor cells in vitro

Blut
I RutenfranzH Kirchner

Abstract

The effects of human interferon gamma (IFN gamma) encapsulated into liposomes were investigated in vitro. Monocytes were induced to release a cytotoxic factor with either IFN gamma encapsulated into liposomes, free IFN gamma or lipopolysaccharide (LPS). If IFN gamma was applied in the liposomal form, less IFN activity was required to stimulate monocytes. Most of the cytotoxic factor was secreted during the first 4 h of stimulation. The cytotoxic factor in supernatants from PMNLs was completely neutralized by a monospecific polyclonal antiserum to tumor necrosis factor (TNF). Combining subthreshold doses of IFN gamma liposomes or IFN gamma with lipopolysaccharide synergistically enhanced the release of TNF. In fluorescence analysis, altered expression of the class II HLA-DR antigen on LeuM3 positive monocytes was induced with IFN gamma liposomes as well as with IFN gamma. Not only monocytes but also natural killer (NK) cells were stimulated to higher cytotoxicity by IFN gamma liposomes in a dose-dependent manner. In comparison with IFN gamma, the same amount of activity was necessary for adequate stimulation of NK-cells against the K562 target cells. Furthermore, the antiproliferative effects of IFN gamma liposomes and free IFN ...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D A EppsteinA B Schreiber
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·A Cerami, B Beutler
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J L UrbanH Schreiber
Feb 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Lopez-BeresteinK Mehta
Jan 1, 1982·Journal of Interferon Research·D A Eppstein
Jul 1, 1983·The Journal of Clinical Investigation·E S KleinermanI J Fidler
Jan 1, 1984·Journal of the National Cancer Institute·H W Ziegler-Heitbrock, G Riethmüller
Nov 1, 1981·The Journal of Experimental Medicine·C F Nathan, Z A Cohn
May 1, 1988·Parasitology Today·A Flisser

❮ Previous
Next ❯

Citations

Jun 15, 1997·Biochemical Pharmacology·H JikiharaA M Poisner
Aug 1, 1991·Scandinavian Journal of Immunology·I RutenfranzH Kirchner
Oct 1, 1991·Journal of Microencapsulation

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.