Interferon-gamma in the diagnosis and pathogenesis of pelvic inflammatory disease

American Journal of Obstetrics and Gynecology
J A GrifoS S Witkin

Abstract

Serologic markers were evaluated to determine if they could aid in the differential diagnosis of pelvic inflammatory disease in 48 consecutive women seeking evaluation for pelvic pain. On the basis of clinical and microbiologic parameters, 29 patients (60.4%) were diagnosed as having pelvic inflammatory disease. Neisseria gonorrhoeae only was isolated from the cervix of eight (27.6%) patients with pelvic inflammatory disease, five (17.2%) had only Chlamydia, and two (6.9%) had Neisseria and Chlamydia, whereas in 15 (48.3%) patients no pathogen was isolated. Interferon-gamma was present in significantly more sera (p less than 0.025) from patients with pelvic inflammatory disease (65.5%) than from women without pelvic inflammatory disease (15.8%). Sera from 10 healthy women lacked detectable interferon-gamma. In patients with only Neisseria, seven (87.5%) had circulating interferon-gamma; three (60%) of the women with only Chlamydia, one (50%) woman with Neisseria and Chlamydia, and eight (57.1%) with no identified pathogens were also positive for interferon-gamma. Sera from 11 of 28 patients with pelvic inflammatory disease (39%) but only one of 19 sera from women without pelvic inflammatory disease (5%) also inhibited the Candi...Continue Reading

Citations

Dec 4, 2012·Journal of Obstetrics and Gynaecology of India·Sunanda BharatnurDamayanthi Krishnamohan
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W L BeattyR P Morrison
Feb 18, 1994·Annals of the New York Academy of Sciences·W CatesP A Marchbanks
Jan 1, 1993·Infectious Diseases in Obstetrics and Gynecology·M TothS S Witkin
Jan 1, 1994·Infectious Diseases in Obstetrics and Gynecology·J Paavonen, M Lehtinen
Jan 1, 1995·Infectious Diseases in Obstetrics and Gynecology·S S Witkin
Feb 1, 1993·Genitourinary Medicine·L Weström, P Wölner-Hanssen
Jan 5, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·E Y BraginaG A Dmitriev
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Tanvi AgrawalAruna Mittal
Aug 30, 2006·American Journal of Reproductive Immunology : AJRI·Jennifer M SmithLi Shen
Jun 1, 1992·Journal of Assisted Reproduction and Genetics·F LicciardiS S Witkin
May 20, 2000·Annals of the New York Academy of Sciences·J N Bontis, K D Dinas
Nov 5, 1997·Annals of the New York Academy of Sciences·R SeracchioliE Porcu
Apr 7, 1998·Infection and Immunity·J U IgietsemeH D Caldwell
Sep 1, 1993·The American Journal of Emergency Medicine·F L CounselmanJ S Weiseman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.