Interferon-gamma in the serum and effusions of cats with feline coronavirus infection.

The Veterinary Journal
Alessia Giordano, Saverio Paltrinieri

Abstract

The aim of this study was to quantify and compare interferon-gamma (IFN-gamma) concentrations in the serum of clinically normal cats infected with feline coronavirus (FCoV) with its concentration in the sera and effusions of cats with feline infectious peritonitis (FIP), a disease associated with infection with a mutated form of FCoV. Clinically normal FCoV-infected cats living in catteries with a high prevalence of FIP had the highest serum IFN-gamma concentrations. The serum concentration of IFN-gamma was not significantly different in cats with FIP compared with clinically normal FCoV-infected animals living in catteries with a low prevalence of the disease. Moreover, the concentration of IFN-gamma was significantly higher in the effusions than in the serum of cats with FIP, probably due to IFN-gamma production within lesions. These findings support the hypothesis that there is a strong, 'systemic' cell mediated immune response in clinically normal, FCoV-infected cats and that a similar process, albeit at a tissue level, is involved in the pathogenesis of FIP.

References

Dec 5, 1998·Veterinary Immunology and Immunopathology·D A Gunn-MooreD A Harbour
Jul 29, 1999·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·S PaltrinieriG Cammarata
Nov 26, 2003·Veterinary Microbiology·Gregg A DeanNiels C Pedersen
Jan 23, 2004·Journal of the American Veterinary Medical Association·Kate E HurleyJanet E Foley
Dec 23, 2004·Journal of Virology·Jolanda D F de Groot-MijnesRaoul J de Groot
Jun 17, 2006·Journal of Feline Medicine and Surgery·Maria E GelainSaverio Paltrinieri

❮ Previous
Next ❯

Citations

Feb 9, 2012·Advances in Virology·Luciana Wanderley MyrrhaMárcia Rogéria de Almeida
Jun 4, 2013·Research in Veterinary Science·G RossiS Paltrinieri
May 20, 2014·The Veterinary Journal·Niels C Pedersen
Nov 2, 2011·The Veterinary Clinics of North America. Small Animal Practice·Yvonne DrechslerPedro Paulo V P Diniz
Feb 27, 2014·Veterinary Pathology·A Kipar, M L Meli
Aug 3, 2019·Journal of Feline Medicine and Surgery·Helen Kedward-DixonChristopher R Helps

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

Statistica
Statsoft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.