Interferon-gamma induces class II antigen expression on cultured rat mesangial smooth muscle cells

Clinical Immunology and Immunopathology
J A Mosquera

Abstract

In this study, Ia antigen expression was detected on cultured rat mesangial smooth muscle (MSM) cells by anti-Ia monoclonal antibodies and indirect immunofluorescence when the cultures were stimulated with recombinant interferon-gamma. This finding may be relevant to the increased expression of Ia on mesangial cells during immunologically mediated glomerulonephritis, since it is possible that Ia expression may be induced not only on mesangial macrophages but also in MSM cells during immunologic pathogenesis of glomerular injury.

References

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Citations

May 16, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jaimar RinconJesus A Mosquera
Jul 22, 2005·Journal of the American Society of Nephrology : JASN·Jennifer R TimoshankoPeter G Tipping
Jul 3, 2019·Frontiers in Cardiovascular Medicine·Karin H SimonsRamon Arens
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer R TimoshankoPeter G Tipping

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