Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells

Endothelium : Journal of Endothelial Cell Research
T ImaizumiK Wakabayashi

Abstract

Interferon-gamma (IFN-gamma) induces expression of multiple genes in endothelial cells. Retinoic acid-inducible gene-I (RIG-I) encodes a protein belonging to the DExH-box family, but details of its physiological function are not clear. RIG-I is induced in leukemia cells by retinoic acid and in endothelial cells by lipopolysaccharide. In the present study, the authors found that IFN-gamma also induces the expression of RIG-I in human umbilical vein endothelial cells. Induction of RIG-I mRNA by IFN-gamma was not altered by the treatment with cycloheximide or interleukin-4. Fluorescent immunostaining and Western blot analysis revealed cytoplasmic distribution of RIG-I. The in situ endothelium in a normal lung tissue was also found to express RIG-I protein. Although the physiological function of RIG-I is still unknown, induction of RIG-I by IFN-gamma may play an important role in inflammatory or immunological reactions in endothelial cells.

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Citations

May 10, 2008·The Journal of Biological Chemistry·Minying ZhangShao-Cong Sun
May 21, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tadaatsu ImaizumiKei Satoh
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Sep 12, 2013·SpringerPlus·Kazuyo SenbaAkira Nishizono
Dec 24, 2010·Critical Reviews in Immunology·Tomoh Matsumiya, Diana M Stafforini
Oct 12, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Gwonhwa SongFuller W Bazer
Nov 18, 2005·Endothelium : Journal of Endothelial Cell Research·T ImaizumiK Wakabayashi
Jan 5, 2011·Protein & Cell·Zhiqiang MiHong Tang
Jun 1, 2011·Protein & Cell·Feng Liu, Jun Gu
Dec 22, 2006·Journal of Dermatological Science·Hideo KitamuraKatsumi Hanada
Mar 21, 2008·Microbiology and Immunology·Tadaatsu ImaizumiKei Satoh
Oct 21, 2006·Microbiology and Immunology·Tadaatsu ImaizumiKei Satoh
Mar 10, 2012·Biochemical and Biophysical Research Communications·Tobias AsdonkSebastian Zimmer
May 9, 2007·Journal of Atherosclerosis and Thrombosis·Tadaatsu ImaizumiKei Satoh
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