Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation

The Journal of Biological Chemistry
Yalai BaiGeorge Tellides

Abstract

Interferon (IFN)-gamma actions on the vessel wall play an important role in the pathogenesis of arteriosclerosis, yet the contribution of different IFN-gamma signaling pathways to the phenotypic modulation of vascular smooth muscle cells (VSMCs) are poorly understood. We investigated the effects of IFN-gamma on VSMCs and arteries through interactions involving signal transducer and activator of transcription (STAT) proteins. In addition to STAT1 activation, IFN-gamma consistently phosphorylated STAT3 in human VSMCs but weakly or not at all in human endothelial cells or mouse VSMCs. STAT3 activation resulted in nuclear translocation of this transcription factor. By selectively inhibiting STAT3 and not STAT1 signaling, we identified a number of candidate IFN-gamma-inducible, STAT3-dependent gene products by microarray analysis. Results for selected genes, including the pro-apoptotic molecules X-linked inhibitor of apoptosis associated factor-1 (XAF1) and Noxa, were verified by real time quantitative reverse transcription-PCR and immunoblot analyses. IFN-gamma-induced STAT3 and STAT1 signaling in VSMCs demonstrated reciprocal inhibition. STAT3 activation by IFN-gamma sensitized VSMCs to apoptosis triggered by both death receptor- ...Continue Reading

References

Feb 24, 1995·The Journal of Biological Chemistry·G S CampbellC Carter-Su
May 31, 1996·The Journal of Biological Chemistry·E CaldenhovenR P de Groot
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F BrombergJ E Darnell
May 5, 1998·Molecular and Cellular Biology·J F BrombergJ E Darnell
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Mar 18, 1999·Journal of Leukocyte Biology·E CaldenhovenR P de Groot
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y AlsayedL C Platanias
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y ShenJ F Bromberg
Feb 15, 2001·Nature Cell Biology·P ListonR G Korneluk
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C V RamanaG R Stark
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M P GilR D Schreiber
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ana P Costa-PereiraValeria Poli
May 27, 2003·Apoptosis : an International Journal on Programmed Cell Death·M Chawla-SarkarE C Borden
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dilip K DebLeonidas C Platanias
Sep 27, 2003·Journal of Neurochemistry·Navjot KaurStanley W Halvorsen
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yinong WangGeorge Tellides
Jul 31, 2004·The Journal of Biological Chemistry·Yulan Qing, George R Stark
Jan 15, 2005·Biochemical and Biophysical Research Communications·Chilakamarti V RamanaRichard Enelow
Feb 12, 2005·The Journal of Biological Chemistry·Yaping Sun, Douglas W Leaman
Mar 29, 2005·Nature Cell Biology·Kathrine AbellChristine J Watson
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William R BurnsGeorge Tellides
Jul 15, 2005·Nature Medicine·Guido Kroemer, Seamus J Martin
Oct 26, 2005·Growth Factors·A Stephanou, D S Latchman
Jan 24, 2006·Experimental Cell Research·Peng FangRon G Rosenfeld
Mar 15, 2006·The Journal of Biological Chemistry·Andrew S CowburnEdwin R Chilvers
Mar 31, 2006·The Journal of Biological Chemistry·Hao H Ho, Lionel B Ivashkiv
Apr 8, 2006·The Journal of Biological Chemistry·Ana M GameroAndrew C Larner
Oct 10, 2006·The Journal of Biological Chemistry·Yang LuGiichi Takaesu
Mar 17, 2007·Circulation Research·George Tellides, Jordan S Pober

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Citations

Nov 6, 2013·Nature Reviews. Rheumatology·Cornelia M Weyand, Jörg J Goronzy
Sep 16, 2009·Journal of Immunotherapy·Takaya TsunoKathryn C Zoon
Jul 28, 2016·Biochemical and Biophysical Research Communications·Ruishan WangLawrence M Pfeffer
May 9, 2012·Journal of Cellular Biochemistry·Oliver TreeckOlaf Ortmann
May 9, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Marieke C S Boshuizen, Menno P J de Winther
Jun 17, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Jordan S Pober
Sep 8, 2009·Cell Biology International·Yukihiro FurusawaTakashi Kondo
Dec 2, 2008·Cytokine & Growth Factor Reviews·James E McLaren, Dipak P Ramji

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