Interferon-gamma mRNA expression upon in vitro T lymphocyte activation is decreased in rheumatoid arthritis patients

Clinical Immunology and Immunopathology
M B SadoukA Toubert

Abstract

A decreased production of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) upon in vitro stimulation by phytohemagglutinin (PHA) peripheral blood leucocyte in active rheumatoid arthritis (RA) patients has been described as an important immunological abnormality in this disease. However, the molecular level at which this defect might occur has not been fully documented. We have investigated the kinetics of IFN-gamma, interleukin-2 receptor (IL-2 R), and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in RA patients (n = 9) and normal controls (n = 5) after PHA leucocyte activation. We demonstrate here a significantly decreased expression of IFN-gamma mRNA in RA patients without modification of its kinetics associated with a similar IL-1 beta mRNA expression.

References

Sep 1, 1988·European Journal of Immunology·J F GauchatB M Stadler
Jun 1, 1985·The Journal of Experimental Medicine·M KrönkeW C Greene
Apr 1, 1984·Clinical Immunology and Immunopathology·N MiyasakaN Talal

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Citations

Jun 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M L TangA S Kemp
Jan 1, 1996·Scandinavian Journal of Rheumatology·H RepoM Leirisalo-Repo
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y Okamoto, M Nishida
Jan 1, 1995·Scandinavian Journal of Rheumatology·M Leirisalo-RepoH Repo
Jul 1, 1993·Arthritis and Rheumatism·E ChenE N Fish
Aug 1, 1993·Inflammation·M Leirisalo-RepoH Repo
Oct 1, 1996·Seminars in Arthritis and Rheumatism·R Badolato, J J Oppenheim

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