PMID: 9448302Mar 14, 1998Paper

Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection

Proceedings of the National Academy of Sciences of the United States of America
K J MaloyR M Zinkernagel

Abstract

Ig class switching usually occurs as a consequence of cognate interactions between antigen-specific B cells and CD4(+) alphabeta T cells. Vesicular stomatitis virus (VSV) infection of immunocompetent mice induces a rapid T-independent neutralizing IgM response followed by a long-lived T-dependent IgG response. Surprisingly, alphabeta T cell-deficient (TCRalpha-/-) mice also produced neutralizing IgG antibodies when infected with live VSV or with a recombinant vaccinia virus expressing the VSV glycoprotein (Vacc-IND-G), but not when immunized with UV-inactivated VSV (UV-VSV). The neutralizing IgG responses did not require the presence of NK cells or complement, but were crucially dependent on IFN-gamma and were predominantly of the IgG2a isotype. IgG production depended on residual CD3(+) non-alphabeta T cell populations present in the TCRalpha-/- mice, which produced IFN-gamma upon in vitro stimulation. A key role for gammadelta T cells was confirmed by the fact that TCRbeta-/- mice also generated strong neutralizing IgG responses to VSV, whereas TCRbeta-/-delta-/- mice produced very low titers. The neutralizing IgG responses of TCRalpha-/- mice were accompanied by the development of memory B cells, but not by antigen-specific ...Continue Reading

References

Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Jan 1, 1992·Immunology Today·Y J LiuI C MacLennan
Sep 1, 1991·Immunology Today·A ErdeiJ Gergely
Dec 1, 1988·The Journal of Experimental Medicine·J P CoutelierJ van Snick
Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
May 1, 1970·Journal of Virology·R R WagnerS Yamazaki
Jan 1, 1995·Annual Review of Immunology·D T Fearon, R H Carter
Jan 1, 1995·Annual Review of Immunology·J J MondC M Snapper
Jul 1, 1994·International Immunology·P MombaertsA K Bhan
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·J L VineyM J Owen
Jan 1, 1994·Annual Review of Immunology·I C MacLennan
Nov 26, 1993·Science·M F BachmannR M Zinkernagel
Jan 1, 1993·Immunology Today·C M Snapper, J J Mond
Jan 1, 1993·Annual Review of Immunology·D C Parker
Feb 1, 1996·The Journal of Experimental Medicine·E Szomolanyi-Tsuda, R M Welsh
May 1, 1996·The Journal of Experimental Medicine·M F BachmannR M Zinkernagel
Jul 1, 1996·European Journal of Immunology·L DiandaM J Owen
May 1, 1996·Current Biology : CB·A L DeFranco
Oct 1, 1996·The Journal of Experimental Medicine·Y J Liu, J Banchereau

❮ Previous
Next ❯

Citations

Dec 16, 2000·Springer Seminars in Immunopathology·Z Yin, J Craft
Sep 2, 1998·Current Opinion in Immunology·E Szomolanyi-Tsuda, R M Welsh
May 9, 2000·Microbes and Infection·R Sciammas, J A Bluestone
Apr 19, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Haishan LiYiming Shao
Mar 23, 2004·Annual Review of Immunology·Raymond M WelshEva Szomolanyi-Tsuda
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·T FehrR M Zinkernagel
Feb 13, 2007·Immunological Reviews·Bernhard Moser, Matthias Eberl
Feb 2, 2000·International Immunology·D Markine-GoriaynoffJ P Coutelier
Sep 3, 2002·Nature Immunology·Andrew J Macpherson, Alain Lamarre
Jan 22, 2005·Circulation Research·Xinghua ZhouGöran K Hansson
Aug 3, 2007·European Journal of Immunology·Karl S LangRolf M Zinkernagel
Aug 18, 2005·European Journal of Immunology·Michael TuenCatarina E Hioe
Mar 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anja StirnweissAndrea Kröger
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rongcun YangRichard B S Roden
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Byung O LeeTroy D Randall
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·W L William ChangNicole Baumgarth
Jan 23, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda S Woodward DavisMichael J Bevan
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shenghua ZhouRobert W Finberg
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tobias JuntHans Hengartner
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea JegerlehnerMartin F Bachmann
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadia CaccamoAlfredo Salerno
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tian WangErol Fikrig
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco FranchiniMark Suter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.