Interferon-gamma production by Listeria monocytogenes-specific T cells active in cellular antibacterial immunity

European Journal of Immunology
S H KaufmannH Kirchner

Abstract

Cultures of peritoneal exudate T lymphocyte-enriched cells (PETLEC) from Listeria monocytogenes-immune mice, antigen-presenting cells (APC) and heat-killed L. monocytogenes produced high amounts of interferon-gamma (IFN-gamma). High IFN titers were also observed after stimulation of L. monocytogenes-immune cell cultures with the T cell mitogens concanavalin A and phytohemagglutinin. L. monocytogenes-immune PETLEC produced several fold higher IFN titers than normal cell cultures in response to mitogen and antigen. Under both circumstances, APC were required for optimum responses. L. monocytogenes-immune PETLEC participating in IFN production were Lyt 1+23-. IFN-gamma was also produced in cultures of cloned L. monocytogenes-specific T cells. Since the same T cell clone showed antigen-specific proliferative responses and interleukin production in vitro, and could adoptively mediate delayed-type hypersensitivity and anti-listerial protection in vivo, it is suggested that IFN production is a function of specific T cells active in cellular antibacterial immunity.

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Citations

Jan 1, 1984·International Journal of Immunopharmacology·S H KaufmannH Hahn
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A Buchmeier, R D Schreiber
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Feb 1, 1987·European Journal of Immunology·S H KaufmannG De Libero
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P J FrostB Bonavida

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