PMID: 2105504Feb 1, 1990Paper

Interferon gamma regulates binding of two nuclear protein complexes in a macrophage cell line

Proceedings of the National Academy of Sciences of the United States of America
P W FinnL H Glimcher

Abstract

Interferon gamma (IFN-gamma) is a potent inducer of major histocompatibility complex (MHC) antigens during normal immune responses and in abnormal responses in autoimmune disease. In this report we identify two nuclear factors whose binding to the murine E beta class II MHC beta-chain gene is regulated by this cytokine. IFN-gamma stimulation of murine macrophages results in the appearance of increased binding of one protein complex, complex A, and decreased binding of a second, faster migrating protein complex, complex B. Although the contact residues for both of these proteins lie within the highly conserved Y-box transcriptional element, their binding specificity differs. The protein in complex B is a CCAAT-box-binding protein that may be similar or identical to NF-Y or YB1, previously identified class II Y-box-binding proteins. The DNA sequence requirements for the binding of the slower migrating complex, complex A, are not limited to CCAAT-box sequences but include sequences upstream of the Y box. These upstream sequences are required both for IFN-gamma-induced gene transcription and for IFN-gamma-induced modulation of binding activity. These data suggest a model in which upstream sequences contribute to formation of a lymp...Continue Reading

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Citations

Jan 1, 1994·Immunopharmacology·L B IvashkivL H Glimcher
Sep 1, 1994·Pharmacology & Therapeutics·Y Ohmori, T A Hamilton
Nov 1, 1992·Human Immunology·M SugawaraJ L Strominger
Feb 1, 1991·Current Opinion in Immunology·C J Kara, L H Glimcher
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J OnoL H Glimcher
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SugawaraJ L Strominger
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C J LowensteinW J Murphy
Aug 7, 1999·Clinical Reviews in Allergy & Immunology·K H InJ M Drazen
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M FlemingP W Finn
Feb 1, 1994·Molecular and Cellular Biology·P WongT M Wright

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