PMID: 2104683Jan 1, 1990Paper

Interferon-gamma regulation of major histocompatibility class I gene expression in rat cells containing the adenovirus 12 E1A oncogene

Virology
A M Ackrill, G E Blair

Abstract

Interferon-gamma (IFN gamma) treatment of cells expressing the Ad12 E1A oncogene results in an increase in MHC class I antigen expression. The effect of IFN gamma upon both the steady-state level of class I mRNA and the in vitro rate of initiation of transcription of class I genes was studied in a rat cell line containing the Ad12 E1A gene. Results obtained showed a marked increase in steady-state level of cytoplasmic class I mRNA; however, a concomitant increase in the rate of transcription of class I genes was not observed. In contrast IFN gamma was shown to markedly increase the rate of transcription of class I genes in primary baby rat kidney cells.

References

Jun 1, 1986·The Journal of General Virology·P H van der MeideH Schellekens
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R VasavadaR P Ricciardi
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T CollinsJ S Pober
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C DaniJ M Blanchard
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K B EagerR P Ricciardi
Jun 15, 1983·Journal of Molecular Biology·A J MintyM E Buckingham

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