Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?

Journal of Clinical Microbiology
Niaz BanaeiMadhukar Pai

Abstract

Interferon gamma release assays (IGRAs) are blood-based tests intended for diagnosis of latent tuberculosis infection (LTBI). IGRAs offer logistical advantages and are supposed to offer improved specificity over the tuberculin skin test (TST). However, recent serial testing studies of low-risk individuals have revealed higher false conversion rates with IGRAs than with TST. Reproducibility studies have identified various sources of variability that contribute to nonreproducible results. Sources of variability can be broadly classified as preanalytical, analytical, postanalytical, manufacturing, and immunological. In this minireview, we summarize known sources of variability and their impact on IGRA results. We also provide recommendations on how to minimize sources of IGRA variability.

References

Dec 7, 2007·The European Respiratory Journal·P BeffaJ-P Zellweger
Jan 18, 2008·Clinical and Vaccine Immunology : CVI·Sharon PerryJulie Parsonnet
Apr 4, 2009·American Journal of Respiratory and Critical Care Medicine·Richard N van Zyl-SmitKeertan Dheda
Apr 16, 2009·Clinical Microbiology Reviews·Trine H Mogensen
Jun 19, 2009·Clinical and Vaccine Immunology : CVI·A K DetjenA C Hesseling
Aug 28, 2009·Clinical and Vaccine Immunology : CVI·Willeke P J FrankenSandra M Arend
Jan 19, 2010·Nature Medicine·Thomas B ClarkeJeffrey N Weiser
Feb 16, 2010·The Journal of Infection·L M LendersK Dheda
Feb 26, 2010·Clinical and Vaccine Immunology : CVI·Tamara TuuminenIlkka Seppälä
Jun 4, 2010·Journal of Clinical Microbiology·Victor HerreraNiaz Banaei
Jul 13, 2012·Journal of Clinical Microbiology·Madeline SlaterNiaz Banaei
Sep 13, 2012·PloS One·William C WhitworthGerald H Mazurek
Oct 30, 2012·American Journal of Respiratory and Critical Care Medicine·John Z MetcalfeEdward A Graviss
Jan 8, 2014·Clinical Microbiology Reviews·Madhukar PaiNiaz Banaei
Jan 28, 2014·PloS One·William C WhitworthGerald H Mazurek
Mar 13, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Madeline SlaterNiaz Banaei
Aug 12, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marc Roger CouturierNancy Pitstick
Sep 5, 2014·Annals of the American Thoracic Society·Saloua TagmoutiClaudia Denkinger
Oct 2, 2014·American Journal of Respiratory and Critical Care Medicine·Rajiv L Gaur, Niaz Banaei
Apr 15, 2015·The Journal of Infection·Jessica JarvisMarc Tebruegge
May 29, 2015·American Journal of Respiratory and Critical Care Medicine·Thomas C KingPeter Wrighton-Smith

❮ Previous
Next ❯

Citations

Mar 26, 2004·American Journal of Surgery·Ferdinand Serracino-InglottDavid N Anderson
Dec 13, 2005·Best Practice & Research. Clinical Gastroenterology·B J Rembacken
Oct 14, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudia C DoblerRobin G Molella
Jun 1, 2018·Expert Review of Anti-infective Therapy·Delia GolettiFabrizio Cantini
Mar 17, 2017·Journal of Clinical Microbiology·Hee-Won MoonNiaz Banaei
Nov 3, 2017·PloS One·Jerker JonssonThomas Schön
Oct 26, 2018·Journal of Clinical Microbiology·Catherine A HoganNiaz Banaei
Mar 31, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alan J WiggRichard J Woodman
Aug 2, 2017·American Journal of Respiratory and Critical Care Medicine·Niaz Banaei, Madhukar Pai
Dec 27, 2019·The Korean Journal of Internal Medicine·Soo Han KimTae Sun Shim
Feb 23, 2020·The Pediatric Infectious Disease Journal·Cristian Quintana-OrtegaFernando Baquero-Artigao
May 6, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Peng LuWei Lu
Jun 5, 2020·Journal of Clinical Microbiology·Arena ShafequeNiaz Banaei
Jul 25, 2017·American Journal of Respiratory and Critical Care Medicine·Elisa NemesUNKNOWN C-040-404 Study Team and the Adolescent Cohort Study Team
May 28, 2019·Current Pharmaceutical Biotechnology·Ji-Hyun NamJeong-Ran Kim
Aug 10, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Thomas Meier, Martin Enders
Jun 11, 2020·The American Journal of Tropical Medicine and Hygiene·Mao-Shui Wang, Xin-Jie Liu
Feb 23, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sung-Han Kim
Jun 3, 2020·Inflammatory Bowel Diseases·Jana G HashashMiguel D Regueiro
Jan 8, 2020·The Open Respiratory Medicine Journal·Luca CoppetaAndrea Magrini
Nov 24, 2020·Journal of Travel Medicine·Tanya R Diefenbach-ElstobChristina Greenaway
Oct 21, 2016·Microbiology Spectrum·Madhukar Pai, Marcel Behr
Jun 16, 2021·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Oh Joo KweonMi-Kyung Lee
Feb 18, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Henan XinUNKNOWN LATENTTB-NSTM study team

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.