PMID: 9551686Apr 29, 1998Paper

Interferon gamma treatment prevents procollagen gene expression without affecting transforming growth factor-beta1 expression in pig serum-induced rat liver fibrosis in vivo

Journal of Hepatology
I SakaidaK Okita

Abstract

The aim of this study was to investigate the effect of interferon gamma on the synthesis of matrix proteins such as collagens with the relation to transforming growth factor-beta1 expression in vivo. We investigated the effects of interferon gamma in a model of liver fibrosis induced by pig serum in male Wistar rats, which develops fibrosis without an increase in serum alanine aminotransferase (i.e., without hepatocyte injury). Rats were injected with 0.5 ml of pig serum twice a week for 8 weeks with or without 20,000 or 50,000 U of interferon gamma. Interferon gamma at doses up to 50,000 U/day prevented fibrosis, as indicated by reduced hydroxyproline content in the liver. Interferon gamma at 50,000 U/day also reduced expression of type I and III procollagen in the liver. However, the expression of transforming growth factor-beta1 mRNA and protein in the liver was not reduced by interferon gamma. Histologically, interferon gamma at 50,000 U/day also reduced the number of myofibroblast-like cells (activated stellate cells). These results indicate that interferon gamma can prevent fibrosis by inhibiting the activation and proliferation of stellate cells, resulting in reduced expression of procollagen without affecting transformi...Continue Reading

References

Apr 1, 1978·The Keio Journal of Medicine·S InayamaS Saito
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S FargionD Conte
Dec 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Bhunchet, K Wake
Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D C RockeyS L Friedman
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W ChenA Kirn
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J CzajaM A Zern
Nov 30, 1989·The New England Journal of Medicine·A M Di BisceglieJ H Hoofnagle
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C F NathanS E Krown
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G DusheikoM Kew
Nov 14, 1985·The New England Journal of Medicine·C NiederauG Strohmeyer
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
May 1, 1967·Analytical Biochemistry·K I KivirikkoD J Prockop
Sep 1, 1984·The Journal of Clinical Investigation·S A JimenezJ Rosenbloom
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A MallatP Mavier
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A PietrangeloE Ventura
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P BedossaM Chojkier
Jan 14, 1993·Journal of Immunological Methods·D Danielpour
May 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G S BaroniA Benedetti
Apr 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E BhunchetK Wake

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Citations

Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I SakaidaK Okita
Feb 22, 2003·Journal of Biomedical Science·Yi-Tsau HuangYau-Huei Wei
Aug 12, 2009·Hepatology International·Tomohiro OgawaKazuo Ikeda
Sep 29, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·C C BaanW Weimar
Apr 12, 2000·Journal of Gastroenterology and Hepatology·I Shimizu
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NakamuraH Ueno
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H YoshijiH Fukui
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yutaka InagakiIsao Okazaki
Jul 5, 2007·Journal of Gastroenterology and Hepatology·Liesbeth DesmyterCuiying Chen
Dec 8, 2005·American Journal of Physiology. Renal Physiology·Myrto GiannopoulouYouhua Liu
Jan 19, 2010·European Journal of Pharmacology·Hong SunXiao-Ping Pu
Apr 28, 2006·Journal of Viral Hepatitis·A J MuirD C Rockey
Jan 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Yuqing LiuTao Ye
Oct 30, 2009·The Journal of Investigative Dermatology·Hee Jung KimHyun Jeong Park
Oct 9, 2008·The Journal of Veterinary Medical Science·Yuka KudoKatsuhiro Shinjo
Sep 6, 2007·The Journal of Toxicological Sciences·Yohei MiyamotoMari Miyamoto
Nov 22, 2011·Life Sciences·Toru KonoMasashi Yoneda
Sep 5, 2003·Cell Transplantation·Norikuni ShibataNaoya Kobayashi
Dec 21, 2004·World Journal of Gastroenterology : WJG·Chun-Song WuCheng-Hao Li
Dec 31, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yuqing LiuSheung Tat Fan
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Isao SakaidaKiwamu Okita
Mar 13, 2008·The Biochemical Journal·Karen WallaceMatthew C Wright
Apr 7, 2004·Journal of Biomedical Science·Yi-Chao HsuYi-Tsau Huang
May 24, 2006·World Journal of Gastroenterology : WJG·Jie-Ting TangEn-Lin Li

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