Interferon immunosuppression: mediation by a suppressor factor.

Infection and Immunity
H M Johnson, J E Blalock

Abstract

Suppression of the in vitro antibody response to sheep erythrocytes by mouse fibroblast interferon occurred by induction of suppressor cell activity in spleen cells. The suppressor cells produced a soluble factor which mediated the immunosuppression. The suppressor factor did not inhibit virus replication; thus, interferon probably regulates the B-cell response by a mechanism that is different from its antiviral effect.

References

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Citations

Aug 1, 1983·Infection and Immunity·H M Johnson, B A Torres
Jul 1, 1984·Clinical Immunology and Immunopathology·W L SibbittA D Bankhurst
Mar 1, 1990·Clinical Immunology and Immunopathology·M P NairS A Schwartz
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Feb 1, 1994·Immunopharmacology and Immunotoxicology·S I ZaidiP K Ray
Nov 1, 1995·Immunopharmacology and Immunotoxicology·S I ZaidiP K Ray
Feb 1, 1981·Biological Reviews of the Cambridge Philosophical Society·V Bocci
Oct 21, 1982·The New England Journal of Medicine·S BorgströmH O Sjögren

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