Interferon in experimental viral infections in mice: tissue interferon levels resulting from the virus infection and from exogenous interferon therapy.

Infection and Immunity
H HeremansP De Somer

Abstract

In mice given single intraperitoneal doses of interferon, serum interferon levels peaked at 1 h postinjection and were reduced to zero at about 8 h. The interferon concentrations in spleen, liver, and lungs were about 100-fold higher than could be expected from the amount of serum contained in these organs. In the brain only low levels of antiviral activity were detected. In mice infected intraperitoneally with Mengo virus, viral replication in the brain occurred around day 4 and was accompanied by the appearance of large amounts of interferon (approximately 10(3.25) U/g). This was preceded, however, by viral replication in the spleen and by the appearance of modest amounts of interferon in spleen and serum. In these mice protection could be obtained with relatively small doses of interferon, provided protection could be obtained with relatively small doses of interferon, provided they were given before the time of maximal levels of endogenous serum interferon. In mice infected intranasally with vesicular stomatitis virus, virus replication in the brain started within 24 to 48 h and increased with time; also, small amounts of interferon (10(2) to 10(2.5) U/g) were already detectable on days 1 and 2. The major peak of virus repl...Continue Reading

References

Sep 1, 1978·Infection and Immunity·H HeremansP de Somer
Oct 1, 1972·Journal of Virology·W E StewartP De Somer
Jul 1, 1967·The Journal of General Virology·N B Finter

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Citations

Jun 13, 1998·Medicine and Science in Sports and Exercise·J M DavisE P Mayer
Sep 1, 1990·Brain, Behavior, and Immunity·M A Segall, L S Crnic
Jan 1, 1981·Archives of Virology·A Billiau
Jan 1, 1994·Biotherapy·N B Finter
Oct 1, 1990·FEMS Microbiology Immunology·B Bizzini, M Fattal-German
Jun 21, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alfons Billiau

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