PMID: 6171815Oct 1, 1981Paper

Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture

Proceedings of the National Academy of Sciences of the United States of America
E WangI Tamm

Abstract

Human beta (fibroblast) interferon inhibits the proliferation of human HeLa-S3 carcinoma cells in suspension culture. Accompanying this effect, the lateral mobility of cell surface receptors for concanavalin A is decreased and the rigidity of the plasma membrane lipid bilayer is increased. The present findings show a marked increase in the number of polymerized actin-containing microfilaments 3 days after treatment of HeLa-S3 cells with beta-interferon (640 units/ml). The cortical region of the treated enlarged cells contains a thick and dense meshwork of 40-70 A microfilaments. The actin nature of the filaments was verified by their ability to bind heavy meromyosin. These results support the concept that beta-interferon induces a coordinated response in the plasma membrane and the underlying microfilaments in both tumor and normal cells.

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Citations

Jul 20, 1984·Biochimica Et Biophysica Acta·Y Tomita, S Hasegawa
Aug 1, 1985·Experimental Cell Research·T HoviI Virtanen
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P B FisherI B Weinstein
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L M PfefferI Tamm
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L M PfefferD B Donner
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·V VieillardE De Maeyer
Jun 1, 1979·Experimental Cell Research·L M PfefferI Tamm
Nov 1, 1990·Differentiation; Research in Biological Diversity·M BirnbaumS Salzberg
Jan 1, 1982·Journal of Interferon Research·L M Pfeffer, I Tamm
Oct 1, 1992·Experimental Dermatology·B M Stanulis-PraegerB A Gilchrest
Jun 15, 1993·Microscopy Research and Technique·F Haimovici, D J Anderson
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·N A Wivel, P M Pitha
Jan 1, 1986·CRC Critical Reviews in Biochemistry·M Rubinstein, P Orchansky
Feb 28, 2002·Journal of Immunological Methods·Anthony Meager
Aug 1, 1983·Molecular and Cellular Biology·D K WilcoxC C Widnell

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