PMID: 6165266Jan 1, 1980Paper

Interferon-induced disease in mice and rats

Annals of the New York Academy of Sciences
I GresserJ Moss

Abstract

Treatment of newborn mice with potent mouse interferon preparations resulted in an acute "early" syndrome characterized by inhibition of growth, delay in maturation of several organs, diffuse liver cell necrosis and death. When interferon treatment was discontinued at 1 week of life, mice appeared to recover, but subsequently developed a progressive glomerulonephritis ("late syndrome"). Treatment of newborn rats with potent rat interferon preparations also resulted in inhibition of growth, delay in maturation, and the subsequent development of glomerulonephritis. After infection at birth with lymphocyte choriomeningitis (LCM) virus, most strains of mice developed a similar acute early syndrome and surviving mice subsequently developed glomerulonephritis. We postulated that the endogenous interferon induced by LCM virus early in life was partially responsible for these syndromes. Administration of a potent anti-mouse interferon serum to LCM virus-infected mice neutralized the circulating endogenous interferon and inhibited the development of both the early and late syndromes. Our results suggest that large amounts of exogenous or endogenous interferon at a crucial stage of rapid growth or development of mice and rats can induce ...Continue Reading

References

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Citations

Jan 1, 1984·Journal of Interferon Research·H Laude, C La Bonnardiere
Mar 20, 2016·Cytokine & Growth Factor Reviews·Insa BuersFrank Rutsch
Dec 3, 2014·Current Opinion in Immunology·Yanick J Crow
Jun 9, 2015·Nature Reviews. Immunology·Yanick J Crow, Nicolas Manel
Jun 5, 2016·Pediatric Rheumatology Online Journal·Stefano VolpiMarco Gattorno
Jun 22, 2016·The Journal of Experimental Medicine·Marije E C MeuwissenGrazia M S Mancini
Sep 24, 2016·La Revue de médecine interne·C Picard, A Belot
Aug 22, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Roli MandhanaCurt M Horvath
Oct 28, 1982·Nature·T Basham, T C Merigan
Dec 7, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dionna W WilliamsJanice E Clements
Apr 2, 2019·Médecine sciences : M/S·Pierre LebonIon Gresser
Jan 12, 2019·Annual Review of Immunology·Carolina UggentiYanick J Crow
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Nov 19, 2019·The Journal of Biological Chemistry·Ashley ZaniJacob S Yount
Sep 20, 2017·Genes & Development·Chaoyong HeLorin E Olson
Dec 5, 2019·Frontiers in Immunology·Catherine F Hatton, Christopher J A Duncan
Dec 18, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Salvatore CazzatoVenerino Poletti
Jun 27, 2021·Current Opinion in Immunology·Louise Malle, Dusan Bogunovic
Sep 10, 2021·Wiley Interdisciplinary Reviews. RNA·Joanna GrochowskaRoman J Szczesny

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