PMID: 11320013Apr 26, 2001Paper

Interferon-induced retinopathy in asymptomatic cancer patients

Ophthalmology
B EsmaeliJ Romaguera

Abstract

Interferon-induced ocular complications, including retinal ischemia and ischemic optic neuropathy, can be associated with significant visual loss. We report three cases of asymptomatic ischemic retinopathy in cancer patients receiving interferon. Retrospective, interventional, noncomparative small case series. Retrospective review of the medical records and fundus photographs. Interferon-induced ischemic retinopathy can occur in asymptomatic cancer patients. The retinal changes are usually reversible with discontinuation of interferon therapy. These three cases underscore the importance of dilated funduscopic examination at baseline and during follow-up, at least every 3 months, for all cancer patients receiving interferon to identify retinal toxicity at its earliest stages. A prospective study evaluating the incidence and severity of interferon retinopathy in cancer patients would be prudent.

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Citations

Nov 5, 2002·Ophthalmology·Paul T FingerSteven A McCormick
Mar 16, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Matthew HoareGraeme J M Alexander
Nov 26, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Wenhu HuangHusam S Younis
Aug 21, 2004·Journal of Clinical Gastroenterology·Richard A Willson
Nov 19, 2004·The British Journal of Ophthalmology·F M CuthbertsonM McKibbin
Dec 9, 2010·The American Journal of the Medical Sciences·Preston H Blomquist
Apr 4, 2008·Cancer Letters·Alessandro M MinisiniGianpiero Fasola
Nov 3, 2005·Survey of Ophthalmology·Madhavi Kurli, Paul T Finger
Mar 29, 2014·Journal of Applied Toxicology : JAT·Hyun-Kyu ParkWoo-Chan Son
Jul 16, 2005·Ocular Immunology and Inflammation·Charles E Thirkill
May 29, 2021·Survey of Ophthalmology·Supriya AroraJay Chhablani

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