Interferon-induced transmembrane protein-3 rs12252-C is associated with rapid progression of acute HIV-1 infection in Chinese MSM cohort

AIDS
Yong-Hong ZhangH Wu

Abstract

The interferon-inducible transmembrane protein-3 (IFITM3) is a protein that restricts multiple pathogenic viruses such as influenza virus. The single-nucleotide polymorphism rs12252-C, which is rare in Caucasian populations, but much more common in the Han Chinese population, has been found in much higher homozygous frequency in patients with severe acute influenza. Until now, there has been no study on the effect of this genetic variant on the clinical control of other viral infections. To investigate the impact of IFITM3-rs12252 genotypes on primary HIV-1 infection progression in an acute HIV-1-infected cohort in Beijing (PRIMO), China. We identified IFITM3-rs12252 genotypes of 178 acute HIV-1-infected patients and 196 HIV-negative candidates from the PRIMO cohort. HIV-1 viral load and CD4(+) T-cell counts were monitored at multiple time points during the first year of infection, and the association between IFITM3-rs12252 genotype and disease progression was evaluated. The current study shows that the IFITM3-rs12252 genetic variant affects the progression of HIV-1 infection, but not the acquisition. A significantly higher frequency of the CC/CT genotypes was found in rapid progressors compared to nonprogressors. Patients with...Continue Reading

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Citations

Jan 6, 2016·Current Opinion in HIV and AIDS·Netanya S Utay, Peter W Hunt
Nov 14, 2015·Cell Reports·Shahin RanjbarAnne E Goldfeld
Sep 2, 2016·Pharmaceutical Statistics·Tarylee ReddyMarc Aerts
Sep 20, 2016·Cell Host & Microbe·Toshana L FosterStuart J D Neil
Mar 4, 2017·PloS One·Michael WinklerStefan Pöhlmann
Aug 31, 2017·Annual Review of Genetics·Adam D KenneyJacob S Yount
Jun 23, 2018·Future Microbiology·Ting ZhangQi Jin
Aug 6, 2020·Frontiers in Cellular and Infection Microbiology·Jéssica S C MartinsAline R Matos
Jan 16, 2019·Nature Chemical Biology·Jennifer S SpenceHoward C Hang
Jan 29, 2019·Frontiers in Microbiology·Xuesen ZhaoJu-Tao Guo
Jul 17, 2019·Pharmaceutical Statistics·Tarylee ReddyGeert Willem Schurink
Feb 28, 2017·The Journal of Clinical Investigation·Maria A StaceyIan R Humphreys
Jan 22, 2019·Current Clinical Microbiology Reports·Ashley Zani, Jacob S Yount
Jan 20, 2021·Annals of Clinical and Translational Neurology·Yi-Song WangAn Jing
Feb 8, 2021·Mayo Clinic Proceedings·Naveen L PereiraSharon Cresci
Aug 10, 2021·World Journal of Virology·Stanislav Vasilev KotsevTsvetelina Velikova

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Methods Mentioned

BETA
ELISA
Flow Cytometry
genotyping

Software Mentioned

GraphPad Prism
RIP
MultiSET
GraphPad

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