PMID: 6168900Jan 1, 1981Paper

Interferon induces an antiviral state in ganglioside-deficient transformed mouse fibroblasts

Medical Microbiology and Immunology
D Schiffmann, K Koschel

Abstract

The antiviral activity of mouse fibroblast interferon against vesicular stomatitis virus was investigated in L-929 mouse fibroblasts and the ganglioside-deficient L-929 mutant cells (ATCC clone NCTC 2071). Although it has been widely reported that gangliosides serve as primary receptors for interferon at the cellular membrane, only a small difference in interferon sensitivity was observed between the wild-type L-929 and the ganglioside-deficient NCTC 2071 cells. It was not possible, however, to overcome this difference by administration of exogenous gangliosides.

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Citations

Jan 1, 1984·Journal of Interferon Research·S L GuptaF H Sarkar
Jul 21, 1998·Annals of the New York Academy of Sciences·A J Yates, A Rampersaud

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