PMID: 8943014Nov 26, 1996Paper

Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo

Proceedings of the National Academy of Sciences of the United States of America
C SgadariG Tosato

Abstract

Human Burkitt lymphoma cell lines give rise to progressively growing subcutaneous tumors in athymic mice. These tumors are induced to regress by inoculation of Epstein-Barr virus-immortalized normal human lymphocytes. In the present study, analysis of profiles of murine cytokine/chemokine gene expression in Burkitt tumor tissues excised from the nude mice showed that expression of the murine alpha-chemokine interferon-inducible protein-10 (IP-10) was higher in the regressing than in the progressive Burkitt tumors. We tested the effects of IP-10 on Burkitt tumor growth in nude mice. Inoculation of established Burkitt tumors either with crude preparations of murine IP-10 or with purified human IP-10 caused visible tumor necrosis in a proportion of the animals, although no complete tumor regressions were observed. Constitutive expression of murine IP-10 in Burkitt cells reduced their ability to grow as subcutaneous tumors, and caused visible tumor necrosis in a proportion of the animals. Histologically, IP-10-treated and IP-10-expressing Burkitt tumors had widespread evidence of tumor tissue necrosis and of capillary damage, including intimal thickening and vascular thrombosis. Thus, IP-10 is an antitumor agent that promotes damag...Continue Reading

References

Oct 1, 1977·Nature·P J PolveriniE R Unanue
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M Farber
Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
Apr 5, 1989·Journal of the National Cancer Institute·H F Dvorak, I Gresser
Mar 1, 1986·The Journal of Experimental Medicine·P P Nawroth, D M Stern
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 1, 1972·Annals of Surgery·J Folkman
Apr 1, 1995·The Journal of Experimental Medicine·P R BurdF C Mills
May 5, 1995·Biochemical and Biophysical Research Communications·R M StrieterP J Polverini
Jul 1, 1995·The Journal of Experimental Medicine·A L AngiolilloG Tosato
Nov 1, 1995·The Journal of Experimental Medicine·F LiaoJ M Farber
Feb 8, 1995·International Journal of Cancer. Journal International Du Cancer·J WolfV Diehl
Sep 1, 1993·The Journal of Experimental Medicine·A D Luster, P Leder

❮ Previous
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Citations

Oct 27, 1998·Journal of Neuroscience Research·S MajumderR M Ransohoff
Dec 31, 1998·Springer Seminars in Immunopathology·G TosatoE S Jaffe
Sep 16, 2011·Cancer Immunology, Immunotherapy : CII·Cailin Moira WilkeWeiping Zou
Sep 1, 2006·Cancer Chemotherapy and Pharmacology·Johnson J LiuMark J McKeage
Dec 30, 2006·Der Pathologe·T RüdigerH K Müller-Hermelink
Sep 11, 2007·Cancer Metastasis Reviews·Seema SinghRakesh K Singh
Apr 13, 2010·Clinical & Experimental Metastasis·Adriana AlbiniUlrich Pfeffer
Feb 17, 2009·Current Oncology Reports·Amy M Fulton
Dec 5, 1998·Journal of Immunological Methods·J M WangS Su
May 17, 2000·Pharmaceutica acta Helvetiae·M J SmitR Leurs
Dec 1, 1999·Transplantation Proceedings·L T SaberA S Ferraz
Oct 3, 2003·Journal of the American College of Surgeons·Leonidas G KoniarisTeresa A Zimmers
Mar 20, 2002·Cytokine & Growth Factor Reviews·Hiroaki IkedaRobert D Schreiber
Jan 12, 2011·Immunology and Cell Biology·Joanna R Groom, Andrew D Luster
Mar 17, 2011·Nature Communications·Ole Audun Werner HaabethAlexandre Corthay
Mar 11, 1998·Journal of Viral Hepatitis·F Balkwill
Jul 5, 2001·Neuropathology and Applied Neurobiology·S H GoldbergE Lavi
Dec 22, 1998·The Journal of Experimental Medicine·S E PikeG Tosato
Dec 6, 2001·The Journal of Experimental Medicine·S IbeT Blankenstein
Jan 19, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K PalmerJ Gauldie
Nov 2, 2001·The American Journal of Surgical Pathology·M W BeatyE S Jaffe
Jul 13, 2001·Journal of Immunotherapy·Hui SunAmy M. Fulton
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Mar 23, 2004·Annual Review of Immunology·Gavin P DunnRobert D Schreiber
Jan 20, 2005·American Journal of Respiratory and Critical Care Medicine·Yong JiangPeng Deng
Jul 30, 2008·Microbial Cell Factories·Julio Villatoro-HernandezRoberto Montes-de-Oca-Luna
Sep 22, 2010·PloS One·Gabriele S V CampanellaAndrew D Luster
Sep 6, 2012·Immunotherapy·Elham Mohit, Sima Rafati
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D MumbergH Schreiber
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SotoA Zlotnik
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchimkeR J Ulevitch
Jul 30, 2014·BMC Cancer·Trevor D HamiltonOliver F Bathe
Jun 1, 2000·Leukemia & Lymphoma·J Teruya-FeldsteinE S Jaffe

❮ Previous
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