PMID: 9420257Jan 7, 1998Paper

Interferon induction as a quasispecies marker of vesicular stomatitis virus populations

Journal of Virology
P I MarcusM J Sekellick

Abstract

The interferon (IFN)-inducing capacity of different isolates of vesicular stomatitis virus (VSV) of the Indiana (IN) and New Jersey (NJ) serotypes were measured to assess the extent of variability of this phenotype. Over 200 preparations of wild-type field isolates, laboratory strains, and plaque-derived subpopulations were examined. Marked heterogeneity was found in the ability of these viruses to induce IFN, covering a 10,000-fold range. A good fit to a normal distribution for the log of the IFN yields suggests a continuum of incremental changes in the viral genome may govern the IFN-inducing capacity of consensus populations derived from independently arising infections. A broad range in the magnitude of these changes, skewed towards inducers of high IFN yields, is consistent with a comparable series of ribonucleotide changes in the VSV genome, a sine qua non of a quasispecies population. Plaque- or vesicle-derived populations displayed standard deviations less than the mean IFN yields, though skewed to higher yielders, whereas populations from field and laboratory samples which differed widely in time and origin of isolation gave standard deviations greater than the means. The plaque isolation of IFN-inducing particles of V...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E DuarteJ Holland
Oct 1, 1990·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M J SekellickP I Marcus
Mar 1, 1990·The American Journal of Tropical Medicine and Hygiene·L L RodriguezG J Letchworth
Dec 1, 1990·Journal of Virology·J C de la Torre, J J Holland
Jan 1, 1986·Methods in Enzymology·P I Marcus
Jan 1, 1986·Methods in Enzymology·M J Sekellick, P I Marcus
Feb 1, 1989·Virology·S T NicholW M Fitch
Mar 1, 1987·Microbiological Reviews·A K Banerjee
Oct 1, 1995·The American Journal of Tropical Medicine and Hygiene·J A VanleeuwenD Waltner-Toews
Apr 1, 1994·Journal of Interferon Research·M J SekellickP I Marcus
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KumarB R Williams
Jul 1, 1994·Journal of Virology·E A DuarteJ J Holland
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S T NicholW M Fitch
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J Holland
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·L L RodríguezS T Nichol

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Citations

Nov 30, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M J SekellickP I Marcus
Feb 15, 2005·Journal of Virology·Philip I MarcusMargaret J Sekellick
Sep 24, 2010·The Journal of General Virology·Gianni Gori SavelliniMaria Grazia Cusi
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M J SekellickP I Marcus
Jan 11, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Philip I Marcus
Mar 17, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·William C WilsonLuis L Rodriguez
Jan 27, 2005·Viral Immunology·Friedemann WeberOtto Haller
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shenghua ZhouRobert W Finberg
Jul 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P Mattana, G C Viscomi
Jul 7, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P I Marcus, M J Sekellick
Apr 26, 2008·Bulletin of Mathematical Biology·Eric L HaseltineJames B Rawlings
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Esteban DomingoCelia Perales
Mar 6, 2019·Nature Microbiology·Pilar Domingo-CalapRafael Sanjuán
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·D S Lyles
Dec 8, 2010·Medical and Veterinary Entomology·P F SmithD G Mead
May 23, 2017·Nature Microbiology·José M CuevasRafael Sanjuán
Dec 14, 2018·Insects·Paula Rozo-LopezBerlin Londoño-Renteria
Jan 12, 2002·Journal of Molecular Biology·Carmen M Ruíz-JaraboEsteban Domingo
Jun 20, 1998·Microbial Pathogenesis·H Bielefeldt-Ohmann, J Barclay
Sep 30, 2021·Annual Review of Virology·Esteban DomingoCelia Perales

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