PMID: 6162936Mar 1, 1981Paper

Interferon induction of natural killer cytotoxicity in human neonates

The Journal of Pediatrics
S KohlL S Loo

Abstract

Low natural killer cytotoxicity has been associated with serious herpes simplex virus infections. Neonates' mononuclear cells had significantly lower NKC to HSV infected (P less than 0.001) and uninfected (P less than 0.005) target cells than did adults' MC. Under appropriate conditions, both neonates' MC to NKC was increased by exogenous human leukocyte interferon. Although neonates' and adults' MC had a similar sensitivity to interferon, there was a significant (P = 0.05) lack of consistency in neonates' MC response. Twenty-three percent (4/17) of neonates' MC samples did not respond with increased NKC in the presence of interferon, unlike adults' MC, all of which demonstrated increased NKC. Neonates' MC did not suppress adults' MC-NKC. These data demonstrate the efficacy of interferon as an NKC stimulator in the neonate, but indicate a heterogeneous response of neonatal cells. We are encouraged with the prospect of clinical trials of interferon to treat severe viral infections in neonates. We urge the inclusion of immune surveillance in these trials.

References

Apr 1, 1979·Cellular Immunology·A SenikH Wigzell
May 4, 1978·The New England Journal of Medicine·T C MeriganR P Fried
Jan 1, 1976·American Journal of Ophthalmology·W M Forrest, H E Kaufman

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Citations

Oct 1, 1982·Journal of Clinical Immunology·J KaplanJ Smith
Jun 1, 1987·European Journal of Clinical Microbiology·C G Prober, A M Arvin
Jan 1, 1982·Springer Seminars in Immunopathology·B Rager-Zisman, B R Bloom
Dec 20, 1980·Lancet·M L Friedlander
Dec 20, 1980·Lancet·S Kohl, L K Pickering
Dec 1, 1996·Transfusion Medicine·S G KutvirtS L Lewis
Mar 1, 1988·Archives of Disease in Childhood·M AricòG R Burgio
Sep 12, 2013·Clinical & Developmental Immunology·Mark R Schleiss
Jun 1, 1984·The Journal of Clinical Investigation·C B Wilson, J E Haas
Jan 1, 1986·The Journal of Pediatrics·C B Wilson
Jan 1, 1993·Vox Sanguinis·A MontanelliE Costa
Dec 14, 2004·AIDS Research and Human Retroviruses·Helene B BernsteinAnthony S Fauci
Apr 1, 1984·Clinics in Dermatology·J S Epstein, G V Quinnan

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