PMID: 6159546Nov 6, 1980Paper

Interferon inhibits transformation by murine sarcoma viruses before integration of provirus

Nature
R J AveryA G Morris

Abstract

Neoplastic transformation by C-type retroviruses requires synthesis of a DNA copy (the provirus) of the RNA genome and its integration into the host cell DNA. We have previously shown that interferon (IFN) can stably prevent transformation of murine fibroblasts by the Kirsten strain of murine sarcoma virus (KiMSV), a murine leukaemia virus (MLV). A series of cell clones (IFN clones), isolated in the presence of IFN (10(4) U ml-1) from cultures of NIH-3T3 cells which had been treated with IFN, and then infected with KiMSV (KiMLV) in conditions where every cell was infected, were shown to be phenotypically untransformed. These untransformed cells did not produce virus or contain rescuable KiMSV. However, cells isolated using an identical procedure, but in the absence of IFN, were uniformly transformed and all produced KiMSV (KiMLV) or contained rescuable KiMSV. It was concluded that IFN either prevents synthesis or integration of the provirus, or else that in the presence of IFN the provirus is integrated such that it is not expressed. We now show that five representative clones contain no detectable KiMSV proviral DNA, and also that the initial stages of infection by KiMSV (KiMLV) are inhibited by IFN treatment. IFN seems to act...Continue Reading

References

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Citations

Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·R McLeodH Cohen
Jan 1, 1984·Pharmacology & Therapeutics·G C Sen
Mar 1, 1995·Pharmacology & Therapeutics·S LandolfoM Gariglio
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·L P TurekP M Howley
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D SergiescuC Chany
Jan 1, 1982·Journal of Interferon Research·W StrubeT Graf
Jan 1, 1985·Journal of Interferon Research·E Paez, M Esteban
Mar 11, 1987·Nucleic Acids Research·T J SmithK E Davies
Jan 1, 1991·Antimicrobial Agents and Chemotherapy·M S SmithJ S Pagano
Oct 29, 1982·Biochemical and Biophysical Research Communications·J D Norton, R J Avery
Nov 18, 2005·Gene Therapy·J L Anderson, T J Hope
Jun 15, 1983·International Journal of Cancer. Journal International Du Cancer·M HuleihelM Aboud
Dec 15, 2016·Frontiers in Immunology·Tomomi ToubaiPavan Reddy
Oct 1, 1983·Journal of Virology·M Huleihel, M Aboud

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