Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection

Infection and Immunity
Helen E RichJohn F Alcorn

Abstract

Influenza kills 30,000 to 40,000 people each year in the United States and causes 10 times as many hospitalizations. A common complication of influenza is bacterial superinfection, which exacerbates morbidity and mortality from the viral illness. Recently, methicillin-resistant Staphylococcus aureus (MRSA) has emerged as the dominant pathogen found in bacterial superinfection, with Streptococcus pneumoniae a close second. However, clinicians have few tools to treat bacterial superinfection. Current therapy for influenza/bacterial superinfection consists of treating the underlying influenza infection and adding various antibiotics, which are increasingly rendered ineffective by rising bacterial multidrug resistance. Several groups have recently proposed the use of the antiviral cytokine interferon lambda (IFN-λ) as a therapeutic for influenza, as administration of pegylated IFN-λ improves lung function and survival during influenza by reducing the overabundance of neutrophils in the lung. However, our data suggest that therapeutic IFN-λ impairs bacterial clearance during influenza superinfection. Specifically, mice treated with an adenoviral vector to overexpress IFN-λ during influenza infection exhibited increased bacterial bur...Continue Reading

References

Sep 24, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J Lindenmann
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·Sadatomo TasakaClaire M Doerschuk
Sep 27, 2002·The New England Journal of Medicine·Michael W FriedJian Yu
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Dec 17, 2002·Nature Immunology·Sergei V KotenkoRaymond P Donnelly
Mar 3, 2004·The Journal of Experimental Medicine·Carla J C de HaasJos A G van Strijp
Feb 16, 2008·Science·Brian D CorbinEric P Skaar
Jul 16, 2008·The Journal of Surgical Research·Charles M RobertsonCraig M Coopersmith
Apr 17, 2009·Journal of Proteome Research·Carolyn M SlupskyPaige Lacy
Dec 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anupa KudvaJohn F Alcorn
Jun 29, 2011·Infection and Immunity·Emma Jane SmithTimothy J Foster
Jul 2, 2011·Nature Reviews. Immunology·Lloyd S Miller, John S Cho
Nov 15, 2011·Seminars in Immunopathology·Kevin M Rigby, Frank R DeLeo
Jan 15, 2013·Frontiers in Cellular and Infection Microbiology·Bénédicte Fournier
Sep 28, 2013·The Journal of Infectious Diseases·Keven M RobinsonJohn F Alcorn
Oct 30, 2013·Pediatrics·Karen K WongLyn Finelli
May 6, 2015·The Journal of Experimental Medicine·Katrina BlazekIrina A Udalova
May 24, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Benjamin LeeJohn F Alcorn
Apr 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hongbo ZhangJieru Wang
Jan 27, 2018·Virology Journal·Giuseppe A SauttoTed M Ross
Feb 13, 2018·The Journal of Clinical Investigation·Jaime L HookJahar Bhattacharya
Feb 15, 2018·Pediatrics·Mei ShangAlicia M Fry
Jul 11, 2018·Frontiers in Immunology·Anja StrehlitzEva Medina

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Citations

Jul 11, 2020·Clinical Science·Ellyse M CipollaJohn F Alcorn
Apr 15, 2020·The Journal of Experimental Medicine·Ludmila Prokunina-OlssonIvan Zanoni
Jul 9, 2020·Frontiers in Cellular and Infection Microbiology·Danielle Ahn, Alice Prince
Dec 11, 2019·The Journal of Experimental Medicine·Achille BroggiIvan Zanoni
Oct 27, 2020·Frontiers in Immunology·Nima TaefehshokrBryan Heit
Oct 27, 2020·Frontiers in Immunology·Helen E RichMichelle L Manni
Aug 3, 2021·Mediators of Inflammation·Mehran ShokriSoheil Ebrahimpour
Jul 2, 2021·Emerging Topics in Life Sciences·Derry K MercerDouglas Fraser-Pitt
Nov 18, 2021·Clinical Microbiology Reviews·Fabián SalazarAdilia Warris

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