Interferon Lambda: Toward a Dual Role in Cancer

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Ahmed LasfarKarine A Cohen-Solal

Abstract

Interferon (IFN)-λ, a type III interferon (IFN), is a member of a new family of pleotropic cytokines that share high similarity with classical IFNs α and β (IFN-α/β), type I IFNs. IFN-λ acts as an antiviral agent and displays distinct biological functions, including tumor suppression. Although it activates the common Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways, similar to IFN-α/β, IFN-λ differentially induces the expression of IFN-stimulated genes (ISGs). Novel evidence indicates that IFN-λ acts quite differently from IFN-α/β under both homeostasis and pathological situations. In contrast to IFN-α/β, IFN-λ is not involved in over-stimulation of the immune response or exacerbation of inflammation. However, the emergence of unexpected characteristics of IFN-λ, in the control of inflammation and promotion of immune suppression and cancer, reveals novel challenges and offers more strategic opportunities in the context of cancer and beyond. In this article, we discuss new evidence and potential consequences associated with the biology of IFN-λ and provide a different vision for building novel therapeutic strategies in oncology.

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Citations

Jun 5, 2019·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sreedhar Chinnaswamy, Marek L Kowalski
Jan 16, 2020·Cancers·Anzhelika KarjalainenMathias Müller
Jul 9, 2020·Immunotherapy·Mohadeseh Haji AbdolvahabLeila Farahmand
Jun 16, 2019·Nature Reviews. Immunology·Liang YePeter Staeheli
Mar 5, 2021·International Journal of Medical Microbiology : IJMM·Iris StolzerClaudia Günther
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Jan 12, 2022·JAAD Case Reports·Caroline SnowdenJaehyuk Choi

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