Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Julie M FoxRalph A Tripp

Abstract

Influenza infection causes an increase in indoleamine 2, 3-dioxygenase (IDO) activity in the lung parenchyma. IDO catabolizes tryptophan into kynurenine, leading to immune dampening. Multiple cell types express IDO, and while IFN-γ upregulates IDO in dendritic cells and macrophages, it is unclear how IDO is affected in respiratory epithelial cells during influenza infection. In this study, the role of IFN-λ in IDO regulation was investigated after influenza infection of respiratory epithelial cells. IDO1 expression increased concurrently with IFN-λ expression. In differentiated NHBE cells, the IDO metabolite was released basolaterally. Recombinant IFN-λ upregulated IDO1 activity, and silencing of IFN-λ decreased IDO1 expression during influenza infection. During IFN-λ stimulation, most differentiated cell types are able to express IDO but during influenza infection, IDO is primarily expressed in uninfected cells. These studies show a role for IDO in the host response to influenza infection, and they provide insights into novel approaches for enhancing vaccine responses and therapeutic approaches.

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Citations

Oct 21, 2016·Molecular Psychiatry·S Georgin-LavialleR Gaillard
Jul 23, 2015·Immunity·Helen M LazearMichael S Diamond
Oct 21, 2016·Biochimica Et Biophysica Acta·Maria AnastasinaDenis E Kainov
Nov 20, 2016·The FEBS Journal·Lana GaelingsDenis E Kainov
Apr 13, 2017·Viral Immunology·Fang Li, Håkan Karlsson
Jan 26, 2017·The FEBS Journal·Yvonne Boergeling, Stephan Ludwig
Jul 19, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ahmed LasfarKarine A Cohen-Solal
Dec 12, 2017·BioMed Research International·Alicja E GrzegorzewskaPaweł P Jagodziński
Jul 18, 2015·Clinical Science·Amanda W S YeungShane R Thomas
Nov 7, 2019·Mediators of Inflammation·Simon LoevenichMarit W Anthonsen
Dec 27, 2016·Frontiers in Immunology·Ahmed LasfarKarine A Cohen-Solal
Jul 11, 2018·Frontiers in Immunology·Meredith J CraneAmanda M Jamieson
Oct 20, 2019·Nature Communications·Rani K PowersJoaquin M Espinosa
Sep 17, 2018·Trends in Immunology·Alexandra I Wells, Carolyn B Coyne

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Methods Mentioned

BETA
ELISA
transfection

Software Mentioned

GraphPad Prism

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