Interferon-Mediated Response to Human Metapneumovirus Infection

Viruses
Ifeanyi K Uche, Antonieta Guerrero-Plata

Abstract

Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response.

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Citations

May 20, 2020·Viruses·Marlies Ballegeer, Xavier Saelens
Nov 3, 2020·Journal of the Pediatric Infectious Diseases Society·Garrett A PerchettiJane Kuypers
Apr 4, 2021·Viruses·Nicolás M S GálvezAlexis M Kalergis
Aug 15, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuya FukudaYukihiko Kawasaki

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