PMID: 6162104Feb 5, 1981Paper

Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon

Nature
A VallbrachtD Niethammer

Abstract

During recent years clinical trials have shown that human leukocyte interferon (HuIFN-alpha) may be useful in the treatment of cancer, but very little has been done concerning the possible use of human fibroblast interferon (HuIFN-beta). Treuner et al. recently reported the successful treatment of a nasopharyngeal carcinoma with HuIFN-beta: in the course of IFN-therapy a HuIFN-beta neutralizing activity appeared in the serum of this patient. We report here that such activity is due to IgG antibodies--this study is the first to present evidence for antigenicity of IFN in a homologous system.

References

Sep 1, 1973·Journal of the National Cancer Institute·H StranderP A Jakobsson
Apr 12, 1980·Lancet·J TreunerP H Hofschneider
Sep 1, 1962·Virology·K PAUCKER, K CANTELL

❮ Previous
Next ❯

Citations

Sep 1, 1987·Journal of Clinical Immunology·M W KonradE C Borden
Jan 1, 1984·Neurosurgical Review·M Nagai, T Arai
Jan 1, 1997·Biotherapy·P H van der Meide, H Schellekens
Apr 1, 1996·European Journal of Drug Metabolism and Pharmacokinetics·S Toon
Jan 1, 1982·Journal of Immunological Methods·P Daubas, E Mogensen
Dec 31, 1984·Journal of Immunological Methods·W P ProtzmanD K Kelsey
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
Sep 1, 1991·Immunology Letters·E VianiA Turano
Jun 1, 1993·Immunology Letters·E MontiA Balsari
May 1, 1990·Immunology Today·K BendtzenE Hippe
Nov 26, 2003·Journal of Biotechnology·Weidong DuE Marion Schneider
Nov 28, 1981·Lancet·K E MogensenB Varet
Jan 15, 1983·Lancet·P W TrownJ U Gutterman
Dec 3, 2002·Veterinary Immunology and Immunopathology·Akira YamamotoSusumu Ueda
Jun 23, 1983·The New England Journal of Medicine·M S HirschR H Rubin
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P W DoetschE E Henderson
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A TuranoA Caruso
Jan 1, 1981·Journal of Interferon Research·J TreunerD Niethammer
Jan 1, 1982·Journal of Interferon Research·A VallbrachtD Niethammer
Jan 1, 1984·Journal of Interferon Research·L J KruegerD E Axelrod
Dec 1, 1986·Journal of Interferon Research·A V Palleroni, P W Trown
Jul 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·O PrümmerH Gallati
Jan 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E PungorS E Grossberg
Dec 1, 1990·Scandinavian Journal of Immunology·M SvensonK Bendtzen
Nov 1, 1993·Scandinavian Journal of Immunology·L TiberioA Balsari
Nov 1, 1993·The Journal of Clinical Investigation·M SvensonK Bendtzen
Oct 1, 1984·Japanese Journal of Medical Science & Biology·S Yamazaki
Jan 1, 1991·La Ricerca in Clinica E in Laboratorio·V Bocci
Sep 30, 1982·Biochimica Et Biophysica Acta·J Taylor-Papadimitriou, F R Balkwill
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·W J Richtsmeier
Apr 27, 2010·Cytokine & Growth Factor Reviews·Masato WatanabeKoh Nakata
Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A VallbrachtB Flehmig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.