PMID: 13948365Jan 1, 1963Paper

Interferon production by mouse leukocytes in vitro and in vivo

The Journal of Experimental Medicine
L A GLASGOW, K HABEL

Abstract

Vaccinia virus penetrates, or is phagocytosed by, mouse leukocytes in vitro. A cytotoxic effect is observed, but no new infectious virus is produced. Vaccinia virus, as infectious particles, is eliminated from a culture of leukocytes at a more rapid rate than can be accounted for by thermal inactivation. Leukocytes infected with vaccinia virus produce a substance with the properties of interferon. The evidence presented suggests that leukocytes also produce interferon in vivo and that this interferon is related to the observed protective effect on the outcome of intracerebral vesicular stomatitis virus challenge in mice. It is postulated that leukocytes, in this manner, may make a positive contribution to the host's defense mechanism and to the process of recovery from viral infections.

References

Dec 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·R B BERG
Mar 1, 1962·The Journal of Experimental Medicine·L A GLASGOW, K HABEL
Feb 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·G T GOODMAN, H KOPROWSKI

Citations

Dec 1, 1963·Journal of Cellular Physiology·M R HILLEMAN
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L B EpsteinT C Merigan
Apr 1, 1967·The Journal of Experimental Medicine·T J Smith, R R Wagner
Jan 1, 1978·Immunological Reviews·A C Allison
Jul 1, 1965·The Journal of Pediatrics·L A GLASGOW
Jan 1, 1967·Archiv für die gesamte Virusforschung·T Tokumaru
Jul 1, 2002·Language, Speech, and Hearing Services in Schools·David J ErtmerMichael L Pachuilo
Jan 1, 1981·Microbiology and Immunology·H TakayamaA Takagi
Jan 1, 1967·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E de MaeyerJ de Maeyer-Guignard
Jan 1, 1966·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P Jullien, E de Maeyer

Related Concepts

Interferons
Leukocytes
Buffalopox virus
Vesicular stomatitis Indiana virus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.