PMID: 13948365Jan 1, 1963Paper

Interferon production by mouse leukocytes in vitro and in vivo

The Journal of Experimental Medicine


Vaccinia virus penetrates, or is phagocytosed by, mouse leukocytes in vitro. A cytotoxic effect is observed, but no new infectious virus is produced. Vaccinia virus, as infectious particles, is eliminated from a culture of leukocytes at a more rapid rate than can be accounted for by thermal inactivation. Leukocytes infected with vaccinia virus produce a substance with the properties of interferon. The evidence presented suggests that leukocytes also produce interferon in vivo and that this interferon is related to the observed protective effect on the outcome of intracerebral vesicular stomatitis virus challenge in mice. It is postulated that leukocytes, in this manner, may make a positive contribution to the host's defense mechanism and to the process of recovery from viral infections.


Dec 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·R B BERG
Mar 1, 1962·The Journal of Experimental Medicine·L A GLASGOW, K HABEL
Feb 1, 1962·Proceedings of the National Academy of Sciences of the United States of America·G T GOODMAN, H KOPROWSKI


Dec 1, 1963·Journal of Cellular Physiology·M R HILLEMAN
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L B EpsteinT C Merigan
Apr 1, 1967·The Journal of Experimental Medicine·T J Smith, R R Wagner
Jan 1, 1978·Immunological Reviews·A C Allison
Jul 1, 1965·The Journal of Pediatrics·L A GLASGOW
Jan 1, 1967·Archiv für die gesamte Virusforschung·T Tokumaru
Jul 1, 2002·Language, Speech, and Hearing Services in Schools·David J ErtmerMichael L Pachuilo
Jan 1, 1981·Microbiology and Immunology·H TakayamaA Takagi
Jan 1, 1967·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·E de MaeyerJ de Maeyer-Guignard
Jan 1, 1966·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·P Jullien, E de Maeyer

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