Interferon receptors during treatment of chronic hepatitis B with interferon

Journal of Gastroenterology and Hepatology
S NakajimaS Yamamoto

Abstract

The in vitro binding of 125I-labelled human alpha-interferon to peripheral blood mononuclear cells from 13 patients with chronic hepatitis B during interferon therapy was assayed in order to identify changes in the number of interferon receptors during treatment. Nine patients were treated with human alpha-interferon (Hu alpha-IFN) or human beta-interferon (Hu beta-IFN) daily for 4 weeks. During therapy, receptor sites per cell decreased by 40%. Two weeks after therapy ceased, this number had returned to the pretreatment level. The other four patients were given Hu alpha-IFN daily for 2 weeks, no injections for 2 weeks, and daily injections for 2 weeks. During both periods of therapy, receptor sites decreased by 40%. The number increased to 94% of the pretreatment level 1 week after the first period and to 101% 2 weeks later. It was 80% 1 week after the second period of injections and 108% 2 weeks later.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·I M Kerr, R E Brown
Dec 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P J FarrellP Lengyel
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A ZilbersteinM Revel
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O YokosukaJ Summers
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F H Sarkar, S L Gupta
Jan 1, 1980·Annals of the New York Academy of Sciences·W K Joklik
Dec 24, 1981·Nature·A A Branca, C Baglioni
Nov 1, 1983·The Journal of General Virology·S YoneharaM Yonehara-Takahashi
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder

❮ Previous
Next ❯

Citations

May 22, 2008·World Journal of Gastroenterology : WJG·Hiroaki OkushinShiro Yuasa
Apr 30, 1998·Journal of Substance Abuse Treatment·C ContoreggiW R Lange
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Milan J Sonneveld, Harry L A Janssen
Feb 1, 1993·Journal of Hepatology·J Y LauG Mieli-Vergani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.