Interferon Regulatory Factor 9 Structure and Regulation

Frontiers in Immunology
Alvin PaulSiew Kit Ng

Abstract

Interferon regulatory factor 9 (IRF9) is an integral transcription factor in mediating the type I interferon antiviral response, as part of the interferon-stimulated gene factor 3. However, the role of IRF9 in many important non-communicable diseases has just begun to emerge. The duality of IRF9's role in conferring protection but at the same time exacerbates diseases is certainly puzzling. The regulation of IRF9 during these conditions is not well understood. The high homology of IRF9 DNA-binding domain to other IRFs, as well as the recently resolved IRF9 IRF-associated domain structure can provide the necessary insights for progressive inroads on understanding the regulatory mechanism of IRF9. This review sought to outline the structural basis of IRF9 that guides its regulation and interaction in antiviral immunity and other diseases.

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Citations

Feb 7, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jiamin HuangBingwei Sun
Sep 18, 2020·BMC Bioinformatics·Nathaniel P Delos SantosChristopher Benner
Feb 23, 2021·Frontiers in Immunology·De Chen ChiangSiew Kit Ng
Dec 5, 2018·Cytokine & Growth Factor Reviews·Nancy Au-Yeung, Curt M Horvath
May 4, 2021·Frontiers in Immunology·Ritu Mishra, Akhil C Banerjea
Jul 10, 2021·Frontiers in Microbiology·Kul Raj RaiJi-Long Chen
Sep 11, 2021·Frontiers in Immunology·James P BarrettDavid J Loane
Oct 3, 2021·Journal of Molecular Biology·Sarah LesageNolwenn Jouvenet
Oct 23, 2021·European Journal of Immunology·Hector Rincon-ArevaloEva V Schrezenmeier

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Methods Mentioned

BETA
transfection
acetylation
nuclear translocation

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