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Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection

Journal of Virology

Jun 20, 2008

Stephane DaffisMichael S Diamond

Abstract

Type I interferon (IFN-alpha/beta) comprises a family of immunomodulatory cytokines that are critical for controlling viral infections. In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules (RIG-I, MDA5, and TLR-3) and induction of inte...read more

Mentioned in this Paper

IFNA1 gene
Mice, Knockout
Kunjin virus
Insula of Reil
Interferon Type I
Interferons
Recombinant Cytokines
IFIH1 gene
DDX58 gene
Specimen Type - Fibroblasts
Paper Details
References
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  • Citations92
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  • References49
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Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

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Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection

Journal of Virology

Jun 20, 2008

Stephane DaffisMichael S Diamond

PMID: 18562536

DOI: 10.1128/jvi.00918-08

Abstract

Type I interferon (IFN-alpha/beta) comprises a family of immunomodulatory cytokines that are critical for controlling viral infections. In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules (RIG-I, MDA5, and TLR-3) and induction of inte...read more

Mentioned in this Paper

IFNA1 gene
Mice, Knockout
Kunjin virus
Insula of Reil
Interferon Type I
Interferons
Recombinant Cytokines
IFIH1 gene
DDX58 gene
Specimen Type - Fibroblasts

Similar Papers Found In These Feeds

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Paper Details
References
  • References49
  • Citations92
12345
  • References49
  • Citations92
12345...
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