PMID: 9181476May 1, 1997Paper

Interferon regulatory factors: growth control and histone gene regulation--it's not just interferon anymore

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
P S VaughanG S Stein

Abstract

Interferon-regulatory factors (IRFs) are a related family of proteins originally identified by their ability to bind a DNA sequence found in the beta-interferon gene and many interferon-stimulated genes. Two well-studied members of this family, IRF-1 and IRF-2, have antagonistic roles in interferon-beta gene regulation: IRF-1 activates this gene, and IRF-2 represses the activation by IRF-1, IRF-1 and IRF-2 have more recently been linked to growth control by displaying tumor suppressor and oncogenic activities, respectively. A possible explanation for the oncogenic activity of IRF-2 is the discovery that IRF-2 can activate a histone gene that is functionally coupled to cell cycle progression. This first report of native IRF-2 playing the role of activator of a gene essential for growth may lead to the discovery of a more general involvement of interferon regulatory factors in mediating growth control.

Citations

Oct 19, 1999·Gene·Y MamaneJ Hiscott
Aug 30, 2002·British Journal of Haematology·Hakan SavliSeppo Pakkala
Dec 22, 1999·The Journal of Experimental Medicine·S GuptaA B Pernis
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giovanna RomeoElisabetta Affabris
Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·B BauvoisP Deterre
Nov 23, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Snehal G ThakkarErnest C Borden
May 21, 2011·Nucleic Acids Research·Pablo De IoannesAneel K Aggarwal
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Apr 16, 2002·British Journal of Cancer·A J SchraderJ Lauber
May 7, 2003·The Journal of Biological Chemistry·Rong-Lin XieAndre J van Wijnen
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K StreetzC Trautwein

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