PMID: 6164954May 1, 1981Paper

Interferon responses of leukocytes in multiple sclerosis

Neurology
P A NeighbourB R Bloom

Abstract

In vitro interferon (IFN) responses of peripheral blood leukocytes to measles virus and to other IFN inducers were determined for multiple sclerosis patients and normal donors. The group mean IFN response to measles virus was significantly lower in patients (15 units) than in normal donors (100 units), and a greater proportion of the patients failed to exhibit a significant IFN response. This defect was not specific for measles virus and was also observed consistently in response to Newcastle disease virus, Poly(I).Poly(C), and concanavalin A. The level of IFN response was not related to the clinical stage of disease.

Citations

Jan 1, 1983·Journal of Neurology·R A Hughes
Nov 1, 1985·Journal of Clinical Immunology·R L HirschK P Johnson
Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M ClanetO Rascol
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert A Bermel, Richard A Rudick
Jul 1, 1997·Journal of the Neurological Sciences·K P WandingerH Kirchner
Nov 4, 1982·The New England Journal of Medicine·D E McFarlin, H F McFarland
Apr 8, 1999·Clinical and Experimental Immunology·S InogésA Sánchez-Ibarrola
Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·A M LiberatiL Palmisano
Apr 1, 1984·Journal of Neuroimmunology·E S Mingioli, D E McFarlin
Aug 1, 1985·Journal of Neuroimmunology·R M Kamin-LewisK P Johnson
Oct 1, 1993·Pharmacology & Therapeutics·P Fitzgerald-Bocarsly
Oct 1, 1985·Immunological Investigations·H C RauchJ Kaplan
Jun 1, 1988·The American Journal of the Medical Sciences·A Schattner
Sep 5, 1998·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·C PetersH Michna
Jan 1, 1991·Clinical Immunology and Immunopathology·P J HertzogI R Mackay
Jan 1, 1984·Annals of the New York Academy of Sciences·D E McFarlin, E S Mingioli
Jan 1, 1984·Annals of the New York Academy of Sciences·U Traugott, C S Raine
Jan 1, 1984·Annals of the New York Academy of Sciences·P A Neighbour
Jan 1, 1984·Annals of the New York Academy of Sciences·J E MerrillG W Ellison
Apr 29, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Vincent C Lombardi, Svetlana F Khaiboullina
Jul 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·C MilaneseA Nespolo
Nov 1, 1996·Multiple Sclerosis : Clinical and Laboratory Research·O AbramskyD Karussis
May 1, 1996·The Journal of International Medical Research·D SquillacoteW Sheremata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.