Abstract
Non-cytopathic bovine viral diarrhea virus (ncpBVDV) induces immune responses mediated by chemokines and interferon (IFN) stimulated genes (ISGs). Cultured bovine peripheral blood mononuclear cells (PBMC) from ncpBVDV-naïve cattle were used herein to demonstrate that BVDV infection modulates chemokine receptor 4 (CXCR4), CXCL12, IFN-I, ISGs and selected immune cell marker (CD4, CD8, CD14) mRNAs, and that these acute responses to viral infection are reflected in PBMC cultured with serum from heifers carrying fetuses persistently infected (PI) with ncpBVDV. Infection of PBMC with ncpBVDV increased IFN-β, ISG15, RIG-I, CXCR4, CXCL12, and CD8 mRNA concentrations after 32 h. Culture of PBMC with uterine vein serum from acutely infected heifers, inoculated with ncpBVDV during early gestation to generate PI fetuses, also increased the concentration of CXCR4, RIG-I and ISG15 mRNAs. In vitro PBMC treatment with ncpBVDV or uterine vein serum from acutely infected pregnant heifers activates chemokine, ISG and immune cell responses.
References
May 1, 1992·Veterinary Immunology and Immunopathology·C J HowardJ Brownlie
Nov 15, 1994·Virology·J F RidpathE J Dubovi
Jan 24, 1998·Biochemical and Biophysical Research Communications·M V VolinP F Davies
Feb 6, 1998·Veterinary Microbiology·M BeerO R Kaaden
Jun 20, 1998·Nature·Y R ZouD R Littman
Jul 7, 1998·Seminars in Immunology·T NagasawaT Kishimoto
Jul 28, 1999·The Journal of General Virology·S G RhodesW I Morrison
Mar 25, 2000·Internal Medicine·T Maekawa, T Ishii
Apr 25, 2000·Virus Research·T Collen, W I Morrison
May 29, 2000·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·H Van CampenJ Cavender
Dec 6, 2000·European Journal of Pharmacology·J Di SalvoK A Sullivan
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A HasegawaS Fujita
May 18, 2001·Veterinary Pathology·S SwasdipanM R McGowan
Jun 20, 2001·The Journal of General Virology·E J Glew, C J Howard
Jan 29, 2002·Microbial Pathogenesis·Somchai SwasdipanHelle Bielefeldt-Ohmann
Jun 20, 2002·Veterinary Immunology and Immunopathology·T CollenW I Morrison
Dec 18, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M Stokstad, T Løken
Nov 25, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M StokstadT Løken
Mar 12, 2004·Clinical and Diagnostic Laboratory Immunology·Doris Müller-DobliesAlfred Metzler
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·Akrit SodhiJ Silvio Gutkind
Apr 22, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·R PiccininiA Zecconi
Dec 16, 2006·Biochimica Et Biophysica Acta·John M Busillo, Jeffrey L Benovic
Dec 7, 2007·Virus Research·Natalia P SmirnovaThomas R Hansen
Feb 5, 2008·AIDS Research and Human Retroviruses·Caterina SerraAntonina Dolei
Nov 7, 2008·Leukemia·J A Burger, A Peled
Nov 19, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Megan L ShoemakerThomas R Hansen
Nov 20, 2008·Physiological Genomics·Natalia P SmirnovaThomas R Hansen
Jan 24, 2012·International Journal of Experimental Pathology·Helle Bielefeldt-OhmannThomas R Hansen
Citations
Feb 7, 2013·Reproductive Biology and Endocrinology : RB&E·Keiichiro KizakiKazuyoshi Hashizume
Oct 23, 2012·Biologicals : Journal of the International Association of Biological Standardization·Clayton L Kelling, Christina L Topliff
Apr 20, 2016·Veterinary Immunology and Immunopathology·Pasumarti ManjariAjay Kumar Dang
Jun 5, 2012·Virus Research·Natalia P SmirnovaThomas R Hansen
Oct 25, 2016·Veterinary Microbiology·Brenden Van WykScott Napper
Jun 23, 2019·BMC Genomics·Wenliang LiJieyuan Jiang
Sep 19, 2012·Veterinary Immunology and Immunopathology·Stephen BurrDirk Werling