Interferon stimulated genes, CXCR4 and immune cell responses in peripheral blood mononuclear cells infected with bovine viral diarrhea virus

Research in Veterinary Science
C M WeinerThomas R Hansen

Abstract

Non-cytopathic bovine viral diarrhea virus (ncpBVDV) induces immune responses mediated by chemokines and interferon (IFN) stimulated genes (ISGs). Cultured bovine peripheral blood mononuclear cells (PBMC) from ncpBVDV-naïve cattle were used herein to demonstrate that BVDV infection modulates chemokine receptor 4 (CXCR4), CXCL12, IFN-I, ISGs and selected immune cell marker (CD4, CD8, CD14) mRNAs, and that these acute responses to viral infection are reflected in PBMC cultured with serum from heifers carrying fetuses persistently infected (PI) with ncpBVDV. Infection of PBMC with ncpBVDV increased IFN-β, ISG15, RIG-I, CXCR4, CXCL12, and CD8 mRNA concentrations after 32 h. Culture of PBMC with uterine vein serum from acutely infected heifers, inoculated with ncpBVDV during early gestation to generate PI fetuses, also increased the concentration of CXCR4, RIG-I and ISG15 mRNAs. In vitro PBMC treatment with ncpBVDV or uterine vein serum from acutely infected pregnant heifers activates chemokine, ISG and immune cell responses.

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Citations

Feb 7, 2013·Reproductive Biology and Endocrinology : RB&E·Keiichiro KizakiKazuyoshi Hashizume
Oct 23, 2012·Biologicals : Journal of the International Association of Biological Standardization·Clayton L Kelling, Christina L Topliff
Apr 20, 2016·Veterinary Immunology and Immunopathology·Pasumarti ManjariAjay Kumar Dang
Sep 19, 2012·Veterinary Immunology and Immunopathology·Stephen BurrDirk Werling

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