Interferon α subtypes in HIV infection

Cytokine & Growth Factor Reviews
Kathrin SutterUlf Dittmer

Abstract

Type I interferons (IFN), which are immediately induced after most virus infections, are central for direct antiviral immunity and link innate and adaptive immune responses. However, several viruses have evolved strategies to evade the IFN response by preventing IFN induction or blocking IFN signaling pathways. Thus, therapeutic application of exogenous type I IFN or agonists inducing type I IFN responses are a considerable option for future immunotherapies against chronic viral infections. An important part of the type I IFN family are 12 IFNα subtypes, which all bind the same receptor, but significantly differ in their biological activities. Up to date only one IFNα subtype (IFNα2) is being used in clinical treatment against chronic virus infections, however its therapeutic success rate is rather limited, especially during Human Immunodeficiency Virus (HIV) infection. Recent studies addressed the important question if other IFNα subtypes would be more potent against retroviral infections in in vitro and in vivo experiments. Indeed, very potent IFNα subtypes were defined and their antiviral and immunomodulatory properties were characterized. In this review we summarize the recent findings on the role of individual IFNα subtype...Continue Reading

Citations

Feb 29, 2020·PLoS Pathogens·Renée M Van der SluisPaul U Cameron
Apr 26, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jieliang ChenZhenghong Yuan
Feb 21, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zahra BahariGholam Hossein Meftahi
Oct 16, 2020·Expert Review of Anti-infective Therapy·Franco MaggioloAntonio Di Biagio
May 14, 2021·Journal of Virology·Alexandra TauzinFabrizio Mammano
Jul 31, 2021·World Journal of Diabetes·Bing-Yan LiYe-Di Zhou

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